Kindlin-2 Expression in Peritumoral Stroma Is Associated With Poor Prognosis in Pancreatic Ductal Adenocarcinoma

被引：17

作者：

Mahawithitwong, Prawej ^{[1
]}

Ohuchida, Kenoki ^{[1
]}

Ikenaga, Naoki ^{[1
]}

Fujita, Hayato ^{[1
]}

Zhao, Ming ^{[1
]}

Kozono, Shingo ^{[1
]}

Shindo, Koji ^{[2
]}

Ohtsuka, Takao ^{[1
]}

Mizumoto, Kazuhiro ^{[1
]}

Tanaka, Masao ^{[1
]}

机构：

[1] Kyushu Univ, Dept Surg & Oncol, Fukuoka 8128582, Japan

[2] Kyushu Univ, Dept Anat Pathol, Fukuoka 8128582, Japan

来源：

PANCREAS | 2013年 / 42卷 / 04期

关键词：

Kindlin-2; pancreatic ductal adenocarcinoma; stromal cell; prognostic factor; reverse transcription-polymerase chain reaction; paraffin-embedded tissue samples; CELL-MATRIX ADHESION; GROWTH-FACTOR-BETA; CANCER; PROTEIN; SURVIVAL; GENE; FIBROBLASTS; CARCINOMA; MARKERS; PANCREATICODUODENECTOMY;

D O I：

10.1097/MPA.0b013e318279bd66

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives: Kindlin-2 is a novel focal adhesion protein reported to be expressed in breast, lung, and gastric cancers. This study aimed to investigate the significance of kindlin-2 expression in pancreatic ductal adenocarcinomas (PDACs). Methods: We performed immunohistochemical analysis on kindlin-2 on PDAC samples from 95 patients. We investigated the association between kindlin-2 expression and clinicopathological parameters of PDAC and the survival time of patients with PDAC who underwent pancreatectomy. Results: Kindlin-2 was highly expressed in the peritumoral stroma of PDACs. Stromal kindlin-2 expression was related to nodal metastasis (P = 0.03). Univariate analysis showed that patients with positive kindlin-2 expression had significantly shorter survival times than those with negative kindlin-2 expression (P = 0.01). In addition, multivariate analysis revealed that kindlin-2 expression was an independent factor of poor prognosis in patients with PDAC after R0 resection (RR = 2.15; P = 0.04). Conclusions: Kindlin-2 expression in stromal components is significantly associated with poor prognosis of patients with PDAC, suggesting that kindlin-2 is a prognostic marker for patients with PDAC.

引用

页码：663 / 669

页数：7

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