A study of topical methyl-aminolevulinate red-light photodynamic therapy in the treatment of squamous cell carcinoma-in-situ in Chinese patients: a Singaporean experience

被引:0
作者
Koh, C. S. L. [1 ,2 ]
Chia, H. Y. [2 ]
Theng, C. [2 ]
Chong, W. S. [2 ]
机构
[1] Liverpool Hosp, Dept Dermatol, Liverpool, NSW 2170, Australia
[2] Natl Skin Ctr, Singapore 1130, Singapore
来源
HONG KONG JOURNAL OF DERMATOLOGY & VENEREOLOGY | 2012年 / 20卷 / 02期
关键词
Asian; Bowen's disease; Fitzpatrick skin phototype IV; Photodynamic therapy; BOWENS-DISEASE; GUIDELINES; ERYTHROPLASIA; CRYOTHERAPY; MANAGEMENT; HUMANS; UPDATE;
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Topical photodynamic therapy is used in the treatment of Bowen's disease (BD). This is a retrospective review of the data of Chinese patients with BD who have undergone photodynamic therapy at the National Skin Centre from March 2006 to March 2010. A total of 43 Chinese patients with 56 histologically confirmed BD were included. The clearance rate at 3 months was 73.2%. Pain was the most common side effect. The clearance rate in our patients is lower than rates cited in current literature. Future prospective studies utilizing topical PDT in the treatment of BD in Asian skin are needed to evaluate its efficacy in Asian patients.
引用
收藏
页码:53 / 59
页数:7
相关论文
共 22 条
[1]   Methylaminolaevulinate-based photodynamic therapy of Bowen's disease and squamous cell carcinoma [J].
Calzavara-Pinton, P. G. ;
Venturini, M. ;
Sala, R. ;
Capezzera, R. ;
Parrinello, G. ;
Specchia, C. ;
Zane, C. .
BRITISH JOURNAL OF DERMATOLOGY, 2008, 159 (01) :137-144
[2]  
Cecic I, 2001, PHOTOCHEM PHOTOBIOL, V74, P712, DOI 10.1562/0031-8655(2001)074<0712:IOSNRI>2.0.CO
[3]  
2
[4]   Guidelines for management of Bowen's disease: 2006 update [J].
Cox, N. H. ;
Eedy, D. J. ;
Morton, C. A. .
BRITISH JOURNAL OF DERMATOLOGY, 2007, 156 (01) :11-21
[5]  
Cox NH, 1999, BRIT J DERMATOL, V141, P633
[6]   Topical aminolaevulinic acid-photodynamic therapy produces an inflammatory infiltrate but reduces Langerhans cells in healthy human skin in vivo [J].
Evangelou, G. ;
Farrar, M. D. ;
White, R. D. ;
Sorefan, N. B. ;
Wright, K. P. ;
McLean, K. ;
Andrew, S. ;
Watson, R. E. B. ;
Rhodes, L. E. .
BRITISH JOURNAL OF DERMATOLOGY, 2011, 165 (03) :513-519
[7]   Photodynamic Therapy-Induced Immunosuppression in Humans Is Prevented by Reducing the Rate of Light Delivery [J].
Frost, Georgia A. ;
Halliday, Gary M. ;
Damian, Diona L. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (04) :962-968
[8]  
Gollnick SO, 2001, PHOTOCHEM PHOTOBIOL, V74, P811, DOI 10.1562/0031-8655(2001)074<0811:IDNPAR>2.0.CO
[9]  
2
[10]   Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells [J].
Hadjur, C ;
Richard, MJ ;
Parat, MO ;
Jardon, P ;
Favier, A .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1996, 64 (02) :375-381