Resveratrol prevents hepatic steatosis induced by hepatitis C virus core protein

被引：32

作者：

Jiang, Lina ^{[1
,2
]}

Gu, Yu ^{[1
,2
]}

Ye, Jing ^{[1
,2
]}

Liu, Fang ^{[1
,2
]}

Zhao, Yilin ^{[3
]}

Wang, Chao ^{[1
,2
]}

Xu, Yuqiao ^{[1
,2
]}

Cao, Xiangmei ^{[1
,2
]}

Zhang, Liying ^{[1
,2
]}

Dong, Wenpeng ^{[4
]}

Li, Fanfan ^{[5
]}

Wang, Jing ^{[1
,2
]}

Wang, Hui ^{[1
,2
]}

Li, Qing ^{[1
,2
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Pathol, Xian 710032, Shaanxi, Peoples R China

[3] Fourth Mil Med Univ, Dept Respirat, Tangdu Hosp, Xian 710038, Peoples R China

[4] Guangzhou Gen Hosp Guangzhou Mil Command, Dept Cardiovasc Surg, Guangzhou 510010, Guangdong, Peoples R China

[5] Fourth Mil Med Univ, Tangdu Hosp, Dept Oncol, Xian 710038, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2012年 / 34卷 / 12期

基金：

中国国家自然科学基金;

关键词：

HCV core protein; Hepatic steatosis; PPAR-alpha; Resveratrol; Sirt1; CALORIE RESTRICTION; LIPID-PEROXIDATION; SIRT1; RATS; MICE; METABOLISM; ACTIVATION; SURVIVAL; DISEASE; LIVER;

D O I：

10.1007/s10529-012-1034-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hepatitis C virus (HCV) core protein plays an important role in the development of hepatic steatosis in patients with chronic HCV infection. Treatment of C57BL/6 mice infected with HCV core recombinant adenoviruses with resveratrol significantly decreased hepatic triacylglycerols (TAG) while the serum TAG level was unaffected. RT-PCR and Western blotting showed that HCV core protein attenuated the expression of Sirt1 and PPAR-alpha, which would be reversed by resveratrol. This was also confirmed in primary mouse hepatic cells infected with HCV core protein expressing adenovirus. Thus, resveratrol may prevent against hepatic steatosis by blocking the inhibited expression of Sirt1 and PPAR-alpha induced by HCV core protein.

引用

页码：2205 / 2212

页数：8

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