Synthetic peptides have become invaluable biomedical research and medicinal chemistry tools for studying functional roles, i.e., binding or proteolytic activity, naturally-occurring regions' immunogenicity in proteins and developing therapeutic agents and vaccines. Synthetic peptides can mimic protein sites; their structure and function can be easily modulated by specific amino acid replacement. They have major advantages, i.e., they are cheap, easily-produced and chemically stable, lack infectious and secondary adverse reactions and can induce immune responses via T- and B-cell epitopes. Our group has previously shown that using synthetic peptides and adopting a functional approach has led to identifying Plasmodium falciparumconserved regions binding to host cells. Conserved high activity binding peptides' (cHABPs) physicochemical, structural and immunological characteristics have been taken into account for properly modifying and converting them into highly immunogenic, protection-inducing peptides (mHABPs) in the experimental Aotus monkey model. This article describes stereo-electron and topochemical characteristics regarding major histocompatibility complex (MHC)-mHABP-T-cell receptor (TCR) complex formation. Some mHABPs in this complex inducing long-lasting, protective immunity have been named immune protection-inducing protein structures (IMPIPS), forming the subunit components in chemically synthesized vaccines. This manuscript summarizes this particular field and adds our recent findings concerning intramolecular interactions (H-bonds or -interactions) enabling proper IMPIPS structure as well as the peripheral flanking residues (PFR) to stabilize the MHCII-IMPIPS-TCR interaction, aimed at inducing long-lasting, protective immunological memory.
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Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USAHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Ahouidi, Ambroise D.
;
Bei, Amy K.
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Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USAHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Bei, Amy K.
;
Neafsey, Daniel E.
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MIT & Harvard, Broad Inst, Microbial Anal Grp, Cambridge, MA 02142 USAHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Neafsey, Daniel E.
;
Sarr, Ousmane
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机构:Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Sarr, Ousmane
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Volkman, Sarah
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Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USAHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Volkman, Sarah
;
Milner, Dan
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Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Queen Elizabeth Cent Hosp, Blantyre Malaria Project, Blantyre, MalawiHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Milner, Dan
;
Cox-Singh, Janet
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Univ Malaysia Sarawak, Fac Med & Hlth Sci, Malaria Res Ctr, Kuching 93150, Sarawak, MalaysiaHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Cox-Singh, Janet
;
Ferreira, Marcelo U.
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Univ Sao Paulo, Dept Parasitol, Inst Biomed Sci, Sao Paulo, BrazilHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Ferreira, Marcelo U.
;
Ndir, Omar
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机构:Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Ndir, Omar
;
Premji, Zul
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Muhimbili Univ, Coll Hlth Sci, Dept Parasitol & Med Entomol, Dar Es Salaam, TanzaniaHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Premji, Zul
;
Mboup, Souleymane
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机构:Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Mboup, Souleymane
;
Duraisingh, Manoj T.
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Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USAHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
机构:
Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USAHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Ahouidi, Ambroise D.
;
Bei, Amy K.
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h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USAHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Bei, Amy K.
;
Neafsey, Daniel E.
论文数: 0引用数: 0
h-index: 0
机构:
MIT & Harvard, Broad Inst, Microbial Anal Grp, Cambridge, MA 02142 USAHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Neafsey, Daniel E.
;
Sarr, Ousmane
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h-index: 0
机构:Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Sarr, Ousmane
;
Volkman, Sarah
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机构:
Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USAHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Volkman, Sarah
;
Milner, Dan
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h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Queen Elizabeth Cent Hosp, Blantyre Malaria Project, Blantyre, MalawiHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Milner, Dan
;
Cox-Singh, Janet
论文数: 0引用数: 0
h-index: 0
机构:
Univ Malaysia Sarawak, Fac Med & Hlth Sci, Malaria Res Ctr, Kuching 93150, Sarawak, MalaysiaHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Cox-Singh, Janet
;
Ferreira, Marcelo U.
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h-index: 0
机构:
Univ Sao Paulo, Dept Parasitol, Inst Biomed Sci, Sao Paulo, BrazilHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Ferreira, Marcelo U.
;
Ndir, Omar
论文数: 0引用数: 0
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机构:Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Ndir, Omar
;
Premji, Zul
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机构:
Muhimbili Univ, Coll Hlth Sci, Dept Parasitol & Med Entomol, Dar Es Salaam, TanzaniaHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Premji, Zul
;
Mboup, Souleymane
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Mboup, Souleymane
;
Duraisingh, Manoj T.
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h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USAHarvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA