A novel use of Grubbs' carbene. Application to the catalytic deprotection of tertiary allylamines

被引：112

作者：

Alcaide, B ^{[1
]}

Almendros, P

Alonso, JM

Aly, MF

机构：

[1] Univ Complutense Madrid, Dept Quim Organ 1, Fac Ciencias Quim, Madrid 28040, Spain

[2] S Valley Univ, Fac Sci Qena, Dept Chem, Qena, Egypt

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 23期

关键词：

D O I：

10.1021/ol0167412

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The first examples accounting for the catalytic deprotection of allylic amines by using reagents different from palladium catalysts have been achieved via Grubbs' carbene-mediated reaction. The current mechanistic hypothesis invokes a nitrogen-assisted ruthenium-catalyzed isomerization, followed by hydrolysis of the enamine intermediate. We believe that an unprecedented mode of ring opening of the ruthena-cyclobutane was involved.

引用

页码：3781 / 3784

页数：4

共 25 条

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