Spatially divergent cardiac responses to nicotinic stimulation of ganglionated plexus neurons in the canine heart

被引:52
作者
Cardinal, Rene [1 ,2 ]
Page, Pierre [1 ,3 ]
Vermeulen, Michel [1 ]
Ardell, Jeffrey L. [4 ]
Armour, Andrew [1 ,2 ]
机构
[1] Hop Sacre Coeur, Ctr Rech, Montreal, PQ H4J 1C5, Canada
[2] Univ Montreal, Dept Pharmacol, Montreal, PQ H3C 3J7, Canada
[3] Univ Montreal, Dept Surg, Montreal, PQ, Canada
[4] E Tennessee State Univ, Dept Pharmacol, Johnson City, TN 37614 USA
来源
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2009年 / 145卷 / 1-2期
基金
美国国家卫生研究院; 加拿大健康研究院;
关键词
Intrinsic cardiac nervous system; Cardiac mapping; Cardiac innervation; Heart rate; Nicotine cardiac ganglionated plexus; EFFERENT VAGAL INNERVATION; ATRIAL-FIBRILLATION; NERVOUS-SYSTEM; FAT PAD; ATRIOVENTRICULAR NODES; PARASYMPATHETIC INNERVATION; INTRINSIC INNERVATION; INTRATHORACIC GANGLIA; MICROSCOPIC ANATOMY; CATHETER ABLATION;
D O I
10.1016/j.autneu.2008.11.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Ganglionated plexuses (GPs) are major constituents of the intrinsic cardiac nervous system, the final common integrator of regional cardiac control. We hypothesized that nicotinic stimulation of individual GPs exerts divergent regional influences, affecting atrial as well as ventricular functions. In 22 anesthetized canines, unipolar electrograms were recorded from 127 atrial and 127 ventricular epicardial loci during nicotine injection (100 mcg in 0.1 ml) into either the 1) right atrial (RA), 2) dorsal atrial, 3) left atrial, 4) inferior vena cava-inferior left atrial, 5) right ventricular, 6) ventral septal ventricular or 7) cranial medial ventricular (CMV) GP. In addition to sinus and AV nodal function, neural effects on atrial and ventricular repolarization were identified as changes in the area subtended by unipolar recordings under basal conditions and at maximum neurally-induced effects. Animals were studied with intact AV node or following ablation to achieve ventricular rate control. Atrial rate was affected in response to stimulation of all 7 GPs with an incidence of 50-95% of the animals among the different GPs. AV conduction was affected following stimulation of 6/7 GP with an incidence of 22-75% among GPs. Atrial and ventricular repolarization properties were affected by atrial as well as ventricular GP stimulation. Distinct regional patterns of repolarization changes were identified in response to stimulation of individual GPs. RAGP predominantly affected the RA and posterior right ventricular walls whereas CMVGP elicited biatrial and biventricular repolarization changes. Spatially divergent and overlapping cardiac regions are affected in response to nicotinic stimulation of neurons in individual GPs. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:55 / 62
页数:8
相关论文
共 48 条
[1]   VENTRICULAR RECOVERY PROPERTIES AND QRST DEFLECTION AREA IN CARDIAC ELECTROGRAMS [J].
ABILDSKOV, JA ;
EVANS, AK ;
LUX, RL ;
BURGESS, MJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1980, 239 (02) :H227-H231
[2]   Evaluation of ventral cardiac denervation as a prophylaxis against atrial fibrillation after coronary artery bypass grafting [J].
Alex, J ;
Guvendik, L .
ANNALS OF THORACIC SURGERY, 2005, 79 (02) :517-520
[3]   SELECTIVE VAGAL INNERVATION OF SINOATRIAL AND ATRIOVENTRICULAR NODES IN CANINE HEART [J].
ARDELL, JL ;
RANDALL, WC .
AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (04) :H764-H773
[4]  
Armour JA, 1997, ANAT REC, V247, P289, DOI 10.1002/(SICI)1097-0185(199702)247:2<289::AID-AR15>3.0.CO
[5]  
2-L
[6]   Cardiac neuronal hierarchy in health and disease [J].
Armour, JA .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 287 (02) :R262-R271
[7]   Origin and pharmacological response of atrial tachyarrhythmias induced by activation of mediastinal nerves in canines [J].
Armour, JA ;
Richer, LP ;
Pagé, P ;
Vinet, A ;
Kus, T ;
Vermeulen, M ;
Nadeau, R ;
Cardinal, R .
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2005, 118 (1-2) :68-78
[8]   SOURCE OF INTRINSIC INNERVATION OF CANINE VENTRICLES - A FUNCTIONAL-STUDY [J].
BLOMQUIST, TM ;
PRIOLA, DV ;
ROMERO, AM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (03) :H638-H644
[9]   TACHYPHYLAXIS OF THE INTRINSIC CARDIAC NERVES TO NICOTINE - EFFECTS ON A-V-NODAL CONDUCTION [J].
BLOMQUIST, TM ;
PRIOLA, DV .
JOURNAL OF AUTONOMIC PHARMACOLOGY, 1992, 12 (01) :51-59
[10]  
BOJSENMOLLER F, 1971, J ANAT, V108, P375