Synthesis of Bicyclic Thiazolidinethiones and Oxazolidinones by Water-Mediated Multicomponent Reactions (MCR) and Ring-Closing Metathesis (RCM)

被引：15

作者：

Stalling, Timo ^{[1
]}

Saak, Wolfgang ^{[1
]}

Martens, Juergen ^{[1
]}

机构：

[1] Carl von Ossietzky Univ Oldenburg, Inst Chem, D-26111 Oldenburg, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 35期

关键词：

Synthetic methods; Multicomponent reactions; Metathesis; Cyclization; Carbon dioxide; Heterocycles; DIASTEREOSELECTIVE SYNTHESIS; CARBON-DIOXIDE; CHIRAL AUXILIARIES; OLEFIN-METATHESIS; FACILE SYNTHESIS; ALDOL ADDITIONS; BOND FORMATION; DERIVATIVES; COMPLEXES; CO2;

D O I：

10.1002/ejoc.201301162

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting with the development of new multicomponent reactions (MCR) in water, hydroxy thiazolidinethiones and oxazolidinones were prepared efficiently in a one-pot procedure. The reaction was carried out under mild conditions, consistent with the principles of green chemistry. These precursors were converted into different dienes containing terminal C-C double bonds by modifying the hydroxy group in one- or two-step sequences. A final ring-closing metathesis (RCM) reaction led to various classes of unsaturated bicycles.

引用

页码：8022 / 8032

页数：11

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