Top-Down Chemoenzymatic Approach to a High-Mannose-Type Glycan Library: Synthesis of a Common Precursor and Its Enzymatic Trimming

被引：60

作者：

Koizumi, Akihiko ^{[1
]}

Matsuo, Ichiro ^{[2
]}

Takatani, Maki ^{[1
]}

Seko, Akira ^{[1
]}

Hachisu, Masakazu ^{[1
]}

Takeda, Yoichi ^{[1
]}

Ito, Yukishige ^{[1
,3
]}

机构：

[1] Japan Sci & Technol Agcy, ERATO, Ito Glycotril Project, Wako, Saitama 3510198, Japan

[2] Gunma Univ, Dept Chem & Chem Biol, Kiryu, Gunma 3768515, Japan

[3] RIKEN, Synthet Cellular Chem Lab, Wako, Saitama 3510198, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 29期

关键词：

carbohydrates; enzymes; glycopeptides; protein folding; synthesis design; PROTEIN-QUALITY CONTROL; ENDOPLASMIC-RETICULUM; FOLDING SENSOR; GLUCOSYLTRANSFERASE RECOGNIZES; MOLECULAR CHAPERONE; SUGAR CHAINS; COMPLEX-TYPE; UDP-GLUCOSE; ER; OLIGOSACCHARIDES;

D O I：

10.1002/anie.201301613

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

From the stacks: A novel method for construction of a high-mannose-type glycan library by systematic enzymatic trimming of a single synthetic Man 9-based precursor was developed. Efficient chemical synthesis of the tetradecasaccharide common precursor and orthogonal enzymatic trimming to obtain all M8-9 and G1M8-9 derivatives was demonstrated. G=glucose, M=mannose. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7426 / 7431

页数：6

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