A population-based study on treatment and outcomes in patients with gastric adenocarcinoma diagnosed with distant interval metastases

被引：5

作者：

Dijksterhuis, Willemieke P. M. ^{[1
,2
]}

Kroese, Tiuri E. ^{[3
,4
]}

Verhoeven, Rob H. A. ^{[1
,2
]}

Van Rossum, Peter S. N. ^{[4
]}

Mook, Stella ^{[4
]}

Mohammad, Nadia Haj ^{[5
]}

Hulshof, Maarten C. C. M. ^{[6
]}

Gisbertz, Suzanne S. ^{[7
]}

Ruurda, Jelle P. ^{[3
]}

van Oijen, Martijn G. H. ^{[1
,2
]}

van Hillegersberg, Richard ^{[3
]}

van Laarhoven, Hanneke W. M. ^{[1
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Dept Med Oncol, Canc Ctr Amsterdam, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[2] Netherlands Comprehens Canc Org IKNL, Dept Res & Dev, POB 19079, NL-3501 DB Utrecht, Netherlands

[3] Univ Utrecht, Univ Med Ctr Utrecht, Dept Surg, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[4] Univ Utrecht, Univ Med Ctr Utrecht, Dept Radiat Oncol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[5] Univ Utrecht, Univ Med Ctr Utrecht, Dept Med Oncol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[6] Univ Amsterdam, Amsterdam UMC, Dept Radiat Oncol, Canc Ctr Amsterdam, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[7] Univ Amsterdam, Amsterdam UMC, Dept Surg, Canc Ctr Amsterdam, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

来源：

EJSO | 2022年 / 48卷 / 09期

关键词：

Gastric neoplasms; Drug therapy; Neoadjuvant therapy; Neoplasm metastases; CANCER; RECURRENCE; PATTERNS;

D O I：

10.1016/j.ejso.2022.03.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: In patients with gastric or gastroesophageal junction (GEJ) cancer treated with curative intent, distant interval metastases may be detected after start of neoadjuvant chemotherapy or during surgery. The aim of this study was to explore characteristics, allocated treatment and overall survival (OS) in gastric/GEJ cancer patients with interval metastases, and to compare OS with synchronous metastatic gastric/GEJ cancer patients who started palliative chemotherapy. Methods: Patients with interval metastases were selected from the Netherlands Cancer Registry by including patients with potentially curable gastric/GEJ adenocarcinoma (2010e2018) who started chemotherapy without concurrent radiotherapy. The OS since start of neoadjuvant treatment of patients with interval metastases was compared with a propensity score-matched cohort of patients with synchronous metastases who received palliative systemic treatment. Results: 164 patients with interval metastases diagnosed in 2010e2018 were included. Metastases were most frequently detected during surgery (83%) and most frequently located in the peritoneum (77%). Peritoneal interval metastases were observed in 63% and 80% of the patients who did and did not have a diagnostic laparoscopy prior to neoadjuvant treatment, respectively (P = 0.041). Median OS was 8.9 months (IQR 5.5-13.4), compared to 8.0 months (IQR 4.1-14.1) in matched synchronous metastatic patients calculated from start of neoadjuvant and palliative systemic treatment, respectively (P = 0.848). Conclusion: This population-based study shows that gastric/GEJ cancer patients who started neoadjuvant treatment and were diagnosed with interval metastases most frequently suffered from peritoneal metastases detected during (exploratory) surgery, even when a diagnostic laparoscopy was performed before start of treatment. OS was comparable to patients with synchronous metastatic gastric/GEJ cancer. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页码：1964 / 1971

页数：8

共 29 条

[1] Gastric Cancer, Version 3.2016 [J].

Ajani, Jaffer A. ;

D'Amico, Thomas A. ;

Almhanna, Khaldoun ;

Bentrem, David J. ;

Chao, Joseph ;

Das, Prajnan ;

Denlinger, Crystal S. ;

Fanta, Paul ;

Farjah, Farhood ;

Fuchs, Charles S. ;

Gerdes, Hans ;

Gibson, Michael ;

Glasgow, Robert E. ;

Hayman, James A. ;

Hochwald, Steven ;

Hofstetter, Wayne L. ;

Ilson, David H. ;

Jaroszewski, Dawn ;

Johung, Kimberly L. ;

Keswani, Rajesh N. ;

Kleinberg, Lawrence R. ;

Korn, W. Michael ;

Leong, Stephen ;

Linn, Catherine ;

Lockhart, A. Craig ;

Ly, Quan P. ;

Mulcahy, Mary F. ;

Orringer, Mark B. ;

Perry, Kyle A. ;

Poultsides, George A. ;

Scott, Walter J. ;

Strong, Vivian E. ;

Washington, Mary Kay ;

Weksler, Benny ;

Willett, Christopher G. ;

Wright, Cameron D. ;

Zelman, Debra ;

McMillian, Nicole ;

Sundar, Hema .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2016, 14 (10) :1286-1312

[2] Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial [J].

Al-Batran, Salah-Eddin ;

Homann, Nils ;

Pauligk, Claudia ;

Goetze, Thorsten O. ;

Meiler, Johannes ;

Kasper, Stefan ;

Kopp, Hans-Georg ;

Mayer, Frank ;

Haag, Georg Martin ;

Luley, Kim ;

Lindig, Udo ;

Schmiegel, Wolff ;

Pohl, Michael ;

Stoehlmacher, Jan ;

Folprecht, Gunnar ;

Probst, Stephan ;

Prasnikar, Nicole ;

Fischbach, Wolfgang ;

Mahlberg, Rolf ;

Trojan, Joerg ;

Koenigsmann, Michael ;

Martens, Uwe M. ;

Thuss-Patience, Peter ;

Egger, Matthias ;

Block, Andreas ;

Heinemann, Volker ;

Illerhaus, Gerald ;

Moehler, Markus ;

Schenk, Michael ;

Kullmann, Frank ;

Behringer, Dirk M. ;

Heike, Michael ;

Pink, Daniel ;

Teschendorf, Christian ;

Loehr, Carmen ;

Bernhard, Helga ;

Schuch, Gunter ;

Rethwisch, Volker ;

von Weikersthal, Ludwig Fischer ;

Hartmann, Joerg T. ;

Kneba, Michael ;

Daum, Severin ;

Schulmann, Karsten ;

Weniger, Joerg ;

Belle, Sebastian ;

Gaiser, Timo ;

Oduncu, Fuat S. ;

Guentner, Martina ;

Hozaeel, Wael ;

Reichart, Alexander .

LANCET, 2019, 393 (10184) :1948-1957

[3]

[Anonymous], 2009, VERSION 1 0 DUTCH CL

[4]

[Anonymous], 2016, DUTCH CLIN PRACTICE

[5] Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial [J].

Bang, Yung-Jue ;

Van Cutsem, Eric ;

Feyereislova, Andrea ;

Chung, Hyun C. ;

Shen, Lin ;

Sawaki, Akira ;

Lordick, Florian ;

Ohtsu, Atsushi ;

Omuro, Yasushi ;

Satoh, Taroh ;

Aprile, Giuseppe ;

Kulikov, Evgeny ;

Hill, Julie ;

Lehle, Michaela ;

Ruschoff, Josef ;

Kang, Yoon-Koo .

LANCET, 2010, 376 (9742) :687-697

[6] Evaluation of PET and laparoscopy in STagIng advanced gastric cancer: a multicenter prospective study (PLASTIC-study) [J].

Brenkman, H. J. F. ;

Gertsen, E. C. ;

Vegt, E. ;

van Hillegersberg, R. ;

Henegouwen, M. I. van Berge ;

Gisbertz, S. S. ;

Luyer, M. D. P. ;

Nieuwenhuijzen, G. A. P. ;

van Lanschot, J. J. B. ;

Lagarde, S. M. ;

de Steur, W. O. ;

Hartgrink, H. H. ;

Stoot, J. H. M. B. ;

Hulsewe, K. W. E. ;

Bilgen, E. J. Spillenaar ;

van Det, M. J. ;

Kouwenhoven, E. A. ;

van der Peet, D. L. ;

Daams, F. ;

van Sandick, J. W. ;

van Grieken, N. C. T. ;

Heisterkamp, J. ;

van Etten, B. ;

Haveman, J. W. ;

Pierie, J. P. ;

Jonker, F. ;

Thijssen, A. Y. ;

Belt, E. J. T. ;

van Duijvendijk, P. ;

Wassenaar, E. ;

van Laarhoven, H. W. M. ;

Wessels, F. J. ;

Mohammad, N. Haj ;

van Stel, H. F. ;

Frederix, G. W. J. ;

Siersema, P. D. ;

Ruurda, J. P. .

BMC CANCER, 2018, 18

[7]

Casparie M, 2007, CELL ONCOL, V29, P19

[8] Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer [J].

Cunningham, David ;

Allum, William H. ;

Stenning, Sally P. ;

Thompson, Jeremy N. ;

Van de Velde, Cornelis J. H. ;

Nicolson, Marianne ;

Scarffe, J. Howard ;

Lofts, Fiona J. ;

Falk, Stephen J. ;

Iveson, Timothy J. ;

Smith, David B. ;

Langley, Ruth E. ;

Verma, Monica ;

Weeden, Simon ;

Chua, Yu Jo .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (01) :11-20

[9] Patterns of initial recurrence in completely resected gastric adenocarcinoma [J].

D'Angelica, M ;

Gonen, M ;

Brennan, MF ;

Turnbull, AD ;

Bains, M ;

Karpeh, MS .

ANNALS OF SURGERY, 2004, 240 (05) :808-816

[10] Hospital volume and beyond first-line palliative systemic treatment in metastatic oesophagogastric adenocarcinoma: A population-based study [J].

Dijksterhuis, Willemieke P. M. ;

Verhoeven, Rob H. A. ;

Pape, Marieke ;

Slingerland, Marije ;

Mohammad, Nadia Haj ;

de Vos-Geelen, Judith ;

Beerepoot, Laurens V. ;

van Voorthuizen, Theo ;

Creemers, Geert-Jan ;

Lemmens, Valery E. P. P. ;

van Oijen, Martijn G. H. ;

van Laarhoven, Hanneke W. M. .

EUROPEAN JOURNAL OF CANCER, 2020, 139 :107-118

← 1 2 3 →