N-heterocyclic carbene-Pd(II)-1-methylimidazole complex-catalyzed Suzuki-Miyaura coupling of 2-chloro-4-aminoquinazolines with arylboronic acids

被引：5

作者：

Bao, Zhen ^{[1
]}

Zhou, Zhi-Yuan ^{[1
]}

Mao, Ye-Ting ^{[1
]}

Shao, Li-Xiong ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Zhejiang, Peoples R China

来源：

TETRAHEDRON | 2020年 / 76卷 / 44期

关键词：

N-heterocyclic carbene-palladium complex; Suzuki-Miyaura coupling; 2-Chloro-4-aminoquinazolines; Arylboronic acids; Synthetic method; BIOLOGICAL EVALUATION; INHIBITORS; SAR; QUINAZOLINES; SULFONATES; AMINATION; CHLORIDES; EFFICIENT; ROUTE;

D O I：

10.1016/j.tet.2020.131548

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Suzuki-Miyaura coupling between 2-chloro-4-aminoquinazolines and arylboronic acids catalyzed by the well-defined N-heterocyclic carbene-PdCl2-1-methylimidazole complex was performed at room temperature, giving the desired products in good to high yields. Through this methodology, a variety of 2-aryl-4-aminoquinazoline derivatives with potential pharmaceutical activities can be achieved under mild reaction conditions. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：6

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