Polarized monolayer cultures of human intestinal epithelial cell lines exposed to intractable proteins - In vitro hazard identification studies

被引：7
作者：
Hurley, Bryan P. [1 ,2 ]
Eaton, Alex D. [1 ]
Zimmermann, Cindi [3 ]
Delaney, Bryan [3 ]
机构：
[1] Massachusetts Gen Hosp, Mucosal Immunol & Biol Res Ctr, 55 Fruit St,Jackson 1402, Boston, MA 02114 USA
[2] Harvard Med Sch, Dept Pediat, Boston, MA USA
[3] DuPont Pioneer, 8325 NW 62ndAvenue, Johnston, IA 50131 USA
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2016年 / 98卷
关键词：
Intractable proteins; Intestinal epithelial cells; Cytotoxicity; PHASEOLUS-VULGARIS LECTINS; GENETICALLY-MODIFIED CROPS; SAFETY ASSESSMENT; PLANT-LECTINS; CACO-2; PERMEABILITY; BINDING; RAT; ACTIVATION; TOXICOLOGY;
D O I：
10.1016/j.fct.2016.11.006
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
[No abstract available]
引用
收藏
页码：262 / 268
页数：7
相关论文
共 33 条
  • [1] Caco-2 monolayers in experimental and theoretical predictions of drug transport
    Artursson, Per
    Palm, Katrin
    Luthman, Kristina
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 : 280 - 289
  • [2] BENBROOK DM, 1990, ONCOGENE, V5, P295
  • [3] Cry1Ab Treatment Has No Effects on Viability of Cultured Porcine Intestinal Cells, but Triggers Hsp70 Expression
    Bondzio, Angelika
    Lodemann, Ulrike
    Weise, Christoph
    Einspanier, Ralf
    [J]. PLOS ONE, 2013, 8 (07):
  • [4] Characteristics and safety assessment of intractable proteins in genetically modified crops
    Bushey, Dean F.
    Bannon, Gary A.
    Delaney, Bryan F.
    Graser, Gerson
    Hefford, Mary
    Jiang, Xiaoxu
    Lee, Thomas C.
    Madduri, Krishna M.
    Pariza, Michael
    Privalle, Laura S.
    Ranjan, Rakesh
    Saab-Rincon, Gloria
    Schafer, Barry W.
    Thelen, Jay J.
    Zhang, John X. Q.
    Harper, Marc S.
    [J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2014, 69 (02) : 154 - 170
  • [5] Plant lectins as carriers for oral drugs: Is wheat germ agglutinin a suitable candidate?
    Dalla Pellegrina, C
    Rizzi, C
    Mosconi, S
    Zoccatelli, G
    Peruffo, A
    Chignola, R
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2005, 207 (02) : 170 - 178
  • [6] Evaluation of protein safety in the context of agricultural biotechnology
    Delaney, Bryan
    Astwood, James D.
    Cunny, Helen
    Conn, Robin Eichen
    Herouet-Guicheney, Corinne
    MacIntosh, Susan
    Meyer, Linda S.
    Privalle, Laura
    Gao, Yong
    Mattsson, Joel
    Levine, Marci
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 : S71 - S97
  • [7] A gene-shuffled glyphosate acetyltransferase protein from Bacillus licheniformis (GAT4601) shows no evidence of allergenicity or toxicity
    Delaney, Bryan
    Zhang, John
    Carlson, Gabrielle
    Schmidt, Jean
    Stagg, Barb
    Comstock, Brad
    Babb, Amy
    Finlay, Carol
    Cressman, Robert F.
    Ladics, Greg
    Cogburn, Amarin
    Siehl, Dan
    Bardina, Luda
    Sampson, Hugh
    Han, Youngshin
    [J]. TOXICOLOGICAL SCIENCES, 2008, 102 (02) : 425 - 432
  • [8] Safety assessment of foods from genetically modified crops in countries with developing economies
    Delaney, Bryan
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2015, 86 : 132 - 143
  • [9] Lectin-mediated bioadhesion: binding characteristics of plant lectins on the enterocyte-like cell lines Caco-2, HT-29 and HCT-8
    Gabor, F
    Stangl, M
    Wirth, M
    [J]. JOURNAL OF CONTROLLED RELEASE, 1998, 55 (2-3) : 131 - 142
  • [10] TRANSCRIPTION FACTOR ATF CDNA CLONES - AN EXTENSIVE FAMILY OF LEUCINE ZIPPER PROTEINS ABLE TO SELECTIVELY FORM DNA-BINDING HETERODIMERS
    HAI, TW
    LIU, F
    COUKOS, WJ
    GREEN, MR
    [J]. GENES & DEVELOPMENT, 1989, 3 (12B) : 2083 - 2090
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