Fibroblast Growth Factor-2, Bone Homeostasis and Fracture Repair

被引：46
作者：
Fei, Yurong [1 ]
Gronowicz, Gloria [2 ]
Hurley, Marja M. [3 ]
机构：
[1] NYU, Coll Dent, New York, NY 10010 USA
[2] Univ Connecticut, Sch Med, Dept Surg, Farmington, CT 06030 USA
[3] Univ Connecticut, Sch Med, Dept Med, Farmington, CT 06030 USA
来源：
CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 19期
关键词：
FGF-2; Bone Homeostasis; Fracture Repair; MESENCHYMAL STEM-CELLS; FRIZZLED-RELATED PROTEIN-1; HUMAN OSTEOGENIC PROTEIN-1; TEMPORAL GENE-EXPRESSION; ADRENAL-MEDULLARY CELLS; MORPHOGENETIC PROTEIN-2; FACTOR RECEPTOR; ENDOTHELIAL-CELLS; OSTEOBLASTIC DIFFERENTIATION; PARATHYROID-HORMONE;
D O I：
10.2174/1381612811319190002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
There remains a great need to develop therapeutic agents to treat critical size defects and non-union fractures and one of the potential agents is recombinant human fibroblast growth factor 2 (FGF-2). We discuss the function of FGF-2 in bone formation, bone resorption, and downstream signaling pathways and review the role of exogenous FGF-2 in fracture healing. The importance of endogenous FGF-2 in bone formation and its potential importance in fracture healing in response to parathyroid hormone (PTH) and bone morphogenetic protein 2 (BMP2) is described. In addition we will review, FGF-2 signaling crosstalk with Wnt signaling and PTH signaling in bone formation and repair. Finally, we discuss the outstanding unresolved issues in the application of FGF-2 as therapeutic agent for bone regeneration.
引用
收藏
页码：3354 / 3363
页数：10
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