Atherosclerotic plaque characterization by spatial and temporal speckle pattern analysis

被引:39
作者
Tearney, GJ
Bouma, BE
机构
[1] Harvard Univ, Sch Med, Pathol Serv, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Wellman Labs Photomed, Boston, MA 02114 USA
关键词
D O I
10.1364/OL.27.000533
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Improved methods are needed to identify the vulnerable coronary plaques responsible for acute myocardial infraction or sudden cardiac death. We describe a method for characterizing the structure and biomechanical properties of atherosclerotic plaques based on speckle pattern fluctuations. Near-field speckle images were acquired from five human aortic specimens ex vivo. The speckle decorrelation. time constant varied significantly for vulnerable aortic plaques (tau = 40 ms) versus stable plaques (tau = 400 ms) and normal aorta (tau = 500 ms). These initial results indicate that different atherosclerotic plaque types may be distinguished by analysis of temporal and spatial speckle pattern fluctuations. (C) 2002 Optical Society of America.
引用
收藏
页码:533 / 535
页数:3
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