PVA-Nigella sativananofibrous mat: antibacterial efficacy and wound healing potentiality

被引：32

作者：

Ali, Ayub ^{[1
]}

Mohebbullah, Md ^{[1
]}

Shahid, Md Abdus ^{[1
]}

Alam, Sadikul ^{[1
]}

Uddin, Md Nur ^{[1
]}

Miah, Md Sumon ^{[1
]}

Jamal, Mohammad Salman Ibna ^{[1
]}

Khan, Md Shablu ^{[1
]}

机构：

[1] Dhaka Univ Engn & Technol DUET, Fac Mech Engn, Dept Text Engn, BIDC Rd, Dhaka 1707, Bangladesh

来源：

JOURNAL OF THE TEXTILE INSTITUTE | 2021年 / 112卷 / 10期

关键词：

Nigella extract; electrospininning; antibacterial and wound healing; CHITOSAN-BASED NANOFIBERS; SATIVA L; COMPOSITE NANOFIBERS; CHEMICAL-COMPOSITION; PLANT-EXTRACTS; CROSS-LINKING; ELECTROSPUN; SKIN; FABRICATION; MEMBRANE;

D O I：

10.1080/00405000.2020.1831168

中图分类号：

TB3 [工程材料学]; TS1 [纺织工业、染整工业];

学科分类号：

0805 ; 080502 ; 0821 ;

摘要：

Over the last few years, nanofibrous mats produced by electrospinning technique showed potential feasibility for skin repairing. It is expected that incorporation of plant extracts into such structures could provide a better performance for biomedical and wound healing applications. The present study deals with the fabrication of PVA based nanofiber mats loaded with the extract of a traditional plant calledNigella sativato enhance the antibacterial, moisture management and wound healing properties. The structure, bonding behavior and moisture management properties of the developed electrospun nanofibers have been investigated. Besides, the antibacterial activity againstStaphylococcus aureus (S. aureus)andEscrcherichia coli (E. coli)bacteria and wound healing activity of the abovementioned mats were also studied. The incorporation ofNigella sativaextract into PVA mats exhibited an excellent antibacterial activity with the formation of inhibition zone of 10.27 mm and 7.8 mm against both bacterial cells. It was observed that the developed mats quickly healed the wound by forming network structure on the skin. The SEM analysis showed the formation of nanofiber having diameter of 178.8 +/- 16.9 nm and the presence ofNigella sativaextract in the electrospun fibers was confirmed by FTIR. Besides, the developed mat was classified as water penetrated according to AATCC test characteristics. Thus, the newly developed nanafibrous mat could turn out to be a suitable material for the wound dressing purpose.

引用

页码：1611 / 1621

页数：11

共 94 条

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