The role of microRNAs in enteroviral infections

被引：19

作者：

Wu, Jing ^{[1
]}

Shen, Li ^{[2
]}

Chen, Jianguo ^{[3
]}

Xu, Huaxi ^{[1
]}

Mao, Lingxiang ^{[1
,2
]}

机构：

[1] Jiangsu Univ, Sch Med, Zhenjiang, Jiangsu, Peoples R China

[2] Zhenjiang Ctr Dis Control & Prevent, Dept Clin Lab, Zhenjiang 212003, Jiangsu, Peoples R China

[3] Zhenjiang First Peoples Hosp, Dept Clin Lab, Nanjing, Jiangsu, Peoples R China

来源：

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES | 2015年 / 19卷 / 05期

关键词：

MicroRNAs; Enterovirus; Infection; COXSACKIEVIRUS B3 BIOSYNTHESIS; C VIRUS TRANSLATION; VIRAL MYOCARDITIS; DOWN-REGULATION; RNA; REPLICATION; EXPRESSION; DIFFERENTIATION; INFLAMMATION; PATHOGENESIS;

D O I：

10.1016/j.bjid.2015.06.011

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The genus Enterooirus, a member of the Picornavirus family, are RNA viruses that can cause poliomyelitis, hand-food-mouth disease, viral meningitis or meningoencephalitis, viral myocarditis and so on. MicroRNAs are a class of highly conserved, small noncoding RNAs recognized as important regulators of gene expression. Recent studies found that MicroRNAs play a significant role in the infection of Enterooirus, such as enterovirus 71, coxsackievirus B3 and other Enterooirus. Enteroviral infection can alter the expression of cellular MicroRNAs, and cellular MicroRNAs can modulate viral pathogenesis and replication by regulating the expression level of viral or host's genes. Herein, this review summarizes the role of MicroRNAs in enteroviral infection. (C) 2015 Elsevier Editora Ltda. All rights reserved.

引用

页码：510 / 516

页数：7

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