New insights into hepatitis B virus biology and implications for novel antiviral strategies

被引：19

作者：

Chen, Jieliang ^{[1
,2
,3
]}

Wu, Min ^{[3
]}

Liu, Kuancheng ^{[1
,2
,4
,5
]}

Zhang, Wen ^{[1
,2
,3
]}

Li, Yaming ^{[1
,2
]}

Zhou, Xiaohui ^{[3
]}

Bai, Lu ^{[1
,2
]}

Yuan, Zhenghong ^{[1
,2
,4
,5
]}

机构：

[1] Fudan Univ, Minist Educ & Hlth, Key Lab Med Mol Virol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Dept Med Microbiol, Sch Basic Med Sci, Shanghai Med Coll, Shanghai 200032, Peoples R China

[3] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Res Unit, Shanghai 201508, Peoples R China

[4] Fudan Univ, Inst Med Microbiol, Shanghai 200032, Peoples R China

[5] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

来源：

NATIONAL SCIENCE REVIEW | 2015年 / 2卷 / 03期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

HBV; cccDNA; HBsAg; persistence; antiviral targets; CLOSED CIRCULAR DNA; HEPADNAVIRUS REVERSE-TRANSCRIPTASE; ALPHA-GLUCOSIDASE INHIBITORS; HUMANIZED MOUSE MODEL; PLUS-STRAND DNA; C VIRUS; IN-VITRO; HUMAN HEPATOCYTES; RNA-BINDING; HEPG2; CELLS;

D O I：

10.1093/nsr/nwv044

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hepatitis B virus (HBV), a small DNA virus with a unique replication mode, can cause chronic hepatitis (CHB), which is characterized by the persistence of the viral covalently closed circular DNA that serves as the template for HBV replication and the production of large amounts of secreted HBV surface antigen (HBsAg) that is present in excess of the levels of infectious virus. Despite the success of currently approved antiviral treatments for CHB patients, including interferon and nucleotide analogs, which suppress HBV replication and reduce the risk of CHB-related liver diseases, these therapies fail to eradicate the virus in most of the patients. With the development of the cell and animal models for HBV study, a better understanding of the HBV life cycle has been achieved and a series of novel antiviral strategies that target different stages of HBV replication have been designed to overcome the viral factors that contribute to HBV persistence. Such basic HBV research advancements and therapeutic developments are the subject of this review.

引用

页码：296 / 313

页数：18

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