Physical Activity in Young BRCA Carriers and Reduced Risk of Breast Cancer

被引:7
作者
Bucy, Ana M. [1 ]
Valencia, Celina I. [2 ]
Howe, Carol L. [3 ]
Larkin, Tyler J. [4 ]
Conard, Kelly D. [5 ]
Anderlik, Eric W. [6 ]
Valdivi, Sarah I. [7 ]
Bea, Jennifer W. [8 ,9 ]
机构
[1] Mary Bridge Childrens Hosp, Tacoma, WA USA
[2] Univ Arizona, Coll Med Tucson, Dept Family & Community Med, Tucson, AZ USA
[3] Univ Arizona, Hlth Sci Lib, Tucson, AZ USA
[4] Univ Incarnate Word, Sch Osteopath Med, Dept Counseling & Educ Psychol, San Antonio, TX USA
[5] Univ Arizona, Coll Med Tucson, Dept Physiol, Tucson, AZ USA
[6] Siemens Healthineers, Walpole, MA USA
[7] New Mexico State Univ, Dept Counseling & Educ Psychol, Las Cruces, NM USA
[8] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Hlth Promot Sci, Tucson, AZ USA
[9] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Hlth Promot Sci, 1295 North Martin Ave, Bldg 202, Tucson, AZ 85724 USA
关键词
SEDENTARY BEHAVIOR; PREVENTION; MUTATIONS;
D O I
10.1016/j.amepre.2022.04.022
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Introduction: A systematic literature review was conducted to determine whether physical activity levels during adolescent and young adult years were associated with a reduced lifetime risk of breast cancer among carriers of deleterious mutations in BRCA1 and BRCA2 genes. Methods: Ovid/MEDLINE, Embase, CENTRAL, WOS, and CINAHL were searched for articles including information about adolescent and young adult physical activity and breast cancer inci-dence among women carrying deleterious BRCA1 and BRCA2 gene mutations (search was initiated in October 2019; last update and full analyses were in March 2021). Independent reviewers screened articles at the title/abstract and full-text levels, resolving differences by consensus with lead authors. The NIH Quality Assessment Tools were used to assess sources of bias. Results: A total of 1,957 unique articles were identified; 5 met inclusion criteria. Samples size ranged from 68 to 1,185. All studies relied on self-reported adolescent and young adult physical activity. One study measured sports involvement; the others measured recreational activity. One large study was null, whereas 4 others showed a reduction in breast cancer incidence later in life with higher adolescent and young adult physical activity (p & LE;0.05). However, the protection was limited to premenopausal breast cancer in 1 of the studies (OR=0.62; 95% CI=0.40, 0.96; p- trend=0.01). In addition, adolescent and young adult physical activity was associated with older age at breast cancer diagnosis in 1 study (p=0.03). Conclusions: A limited number of studies suggest that adolescent and young adult physical activ-ity may reduce or delay the risk of breast cancer incidence among carriers of deleterious mutations in BRCA1 and BRCA2 genes. (C) 2022 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:837 / 845
页数:9
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