Asymmetric Total Synthesis of the Immunosuppressant (-)-Pironetin

被引：44

作者：

Bressy, Cyril ^{[1
]}

Vors, Jean-Pierre ^{[2
]}

Hillebrand, Stefan ^{[3
]}

Arseniyadis, Stellios ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] ESPCI ParisTech, CNRS, Chim Organ Lab, F-75231 Paris 05, France

[2] Bayer CropSci, Lyon, France

[3] Bayer CropSci, Monheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 52期

关键词：

antitumor agents; hydrosilylation; natural products; pentenylation; ring-closing metathesis;

D O I：

10.1002/anie.200802423

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A short, enantioselective total synthesis of the title compound 1 is described. The 14-step synthesis features a highly stereoselective Brown-type pentenylation and a onepot hydrosilylation/ring- closing metathesis (RCM)/protodesilylation sequence as the key steps. PG=protecting group. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：10137 / 10140

页数：4

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