Nanostructured bicontinuous cubic lipid self-assembly materials as matrices for protein encapsulation

被引：106

作者：

Conn, Charlotte E. ^{[1
]}

Drummond, Calum J. ^{[1
]}

机构：

[1] CSIRO Mat Sci & Engn CMSE, Clayton, Vic 3169, Australia

来源：

SOFT MATTER | 2013年 / 9卷 / 13期

基金：

澳大利亚研究理事会;

关键词：

X-RAY-DIFFRACTION; LYOTROPIC LIQUID-CRYSTAL; DRUG-DELIVERY SYSTEMS; MEMBRANE-PROTEINS; CYTOCHROME-C; MONOOLEIN/WATER SYSTEM; WATER PHASES; KINASE-C; TRANSMEMBRANE PEPTIDES; ALPHA-CHYMOTRYPSIN;

D O I：

10.1039/c3sm27743g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We review the use of bicontinuous cubic amphiphile self-assembly materials for protein encapsulation. The unique amphiphilic nature of bicontinuous cubic lipidic phases make them an ideal medium for the encapsulation of soluble, peripheral, and integral membrane proteins. Current and prospective applications for such systems include drug delivery, membrane protein crystallisation, biosensors and biofuel cells. We focus on the impact of the incorporated protein on the structure of the cubic phase, which has a knock-on effect on performance for many end-applications.

引用

页码：3449 / 3464

页数：16

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