Ruthenium (II) complexes containing a new asymmetric ligand: DNA interaction, photocleavage and topoisomerase I inhibition

被引：8

作者：

Liu, Xue-Wen ^{[1
]}

Zhang, Song-Bai ^{[1
]}

Li, Lin ^{[1
]}

Chen, Yuan-Dao ^{[1
]}

Lu, Ji-Lin ^{[1
]}

机构：

[1] Hunan Univ Arts & Sci, Coll Chem & Chem Engn, Changde 415000, Peoples R China

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2013年 / 729卷

基金：

中国国家自然科学基金;

关键词：

Ru(II) complex; Asymmetric ligand; DNA-binding; Photocleavage; Topoisomerase I; MOLECULAR LIGHT SWITCH; POLYPYRIDYL COMPLEXES; ETHIDIUM-BROMIDE; NUCLEIC-ACIDS; BINDING; CAMPTOTHECIN; SPECIFICITY; MECHANISM; CLEAVAGE; DESIGN;

D O I：

10.1016/j.jorganchem.2013.01.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new asymmetric ligand 2-(pyridine-2-yl)-1-H-imidazo[4,5-g]acenaphtho[1',2':2,3] quinoxaline (piaq) and its ruthenium complexes with [Ru(L)(2)(piaq)](2+)(L = bpy (2,2'-bipyridine), phen (1,10-phenanthroline)), have been synthesized, and their DNA-binding, photocleavage and DNA topoisomerase I inhibition properties were measured. Results suggested that both Ru(II) complexes can intercalate into DNA base pairs. Furthermore, the two complexes are efficient DNA-photocleavers under irradiation at 365 nm, and singlet oxygen (O-1(2)) is the active specie in DNA photocleavage. Topoisomerase inhibition and DNA strand passage assay suggested that both complexes are efficient inhibitors of DNA topoisomerase I. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

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