Genetic causality in schizophrenia and bipolar disorder: out with the old and in with the new

被引：36

作者：

Porteous, David ^{[1
]}

机构：

[1] Univ Edinburgh, Western Gen Hosp, Ctr Mol Med, Med Genet Sect, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2008年 / 18卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.gde.2008.07.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Schizophrenia (SZ) and bipolar disorder are highly heritable forms of major mental illness. Great hopes were held out for a major breakthrough with the advent of genome wide association studies, but to date there have been no obvious low hanging fruit. A richer harvest of strong candidates has however emerged from molecular cytogenetics and copy number variant mapping strategies promise to add more. Both strategies identify gene mutations, paving a direct path to biological studies and tests of causality. Risk genes and convergent biological pathways common to both disorders are being revealed, offering hope for a better understanding of aetiological factors and for the development of biomarkers to aid in diagnosis and prognosis.

引用

页码：229 / 234

页数：6

共 45 条

[1]

ALLEN N, NAT GENET IN PRESS

[2]

[Anonymous], 2007, NATURE, V447, P61

[3] Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement [J].

Baum, A. E. ;

Hamshere, M. ;

Green, E. ;

Cichon, S. ;

Rietschel, M. ;

Noethen, M. M. ;

Craddock, N. ;

McMahon, F. J. .

MOLECULAR PSYCHIATRY, 2008, 13 (05) :466-467

[4] A genome-wide association study implicates diacylglycerol kinase η (DGKH) and several other genes in the etiology of bipolar disorder [J].

Baum, A. E. ;

Akula, N. ;

Cabanero, M. ;

Cardona, I. ;

Corona, W. ;

Klemens, B. ;

Schulze, T. G. ;

Cichon, S. ;

Rietschel, M. ;

Noethen, M. M. ;

Georgi, A. ;

Schumacher, J. ;

Schwarz, M. ;

Abou Jamra, R. ;

Hoefels, S. ;

Propping, P. ;

Satagopan, J. ;

Detera-Wadleigh, S. D. ;

Hardy, J. ;

McMahon, F. J. .

MOLECULAR PSYCHIATRY, 2008, 13 (02) :197-207

[5] Schizophrenia and affective disorders - Cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: Clinical and P300 findings in a family [J].

Blackwood, DHR ;

Fordyce, A ;

Walker, MT ;

St Clair, DM ;

Porteous, DJ ;

Muir, WJ .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (02) :428-433

[6] Disrupted in schizophrenia 1 interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia [J].

Camargo, L. M. ;

Collura, V. ;

Rain, J-C ;

Mizuguchi, K. ;

Hermjakob, H. ;

Kerrien, S. ;

Bonnert, T. P. ;

Whiting, P. J. ;

Brandon, N. J. .

MOLECULAR PSYCHIATRY, 2007, 12 (01) :74-86

[7] Opinion - Gene-environment interactions in psychiatry: joining forces with neuroscience [J].

Caspi, Avshalom ;

Moffitt, Terrie E. .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (07) :583-590

[8] Replicating genotype-phenotype associations [J].

Chanock, Stephen J. ;

Manolio, Teri ;

Boehnke, Michael ;

Boerwinkle, Eric ;

Hunter, David J. ;

Thomas, Gilles ;

Hirschhorn, Joel N. ;

Abecasis, Goncalo ;

Altshuler, David ;

Bailey-Wilson, Joan E. ;

Brooks, Lisa D. ;

Cardon, Lon R. ;

Daly, Mark ;

Donnelly, Peter ;

Fraumeni, Joseph F., Jr. ;

Freimer, Nelson B. ;

Gerhard, Daniela S. ;

Gunter, Chris ;

Guttmacher, Alan E. ;

Guyer, Mark S. ;

Harris, Emily L. ;

Hoh, Josephine ;

Hoover, Robert ;

Kong, C. Augustine ;

Merikangas, Kathleen R. ;

Morton, Cynthia C. ;

Palmer, Lyle J. ;

Phimister, Elizabeth G. ;

Rice, John P. ;

Roberts, Jerry ;

Rotimi, Charles ;

Tucker, Margaret A. ;

Vogan, Kyle J. ;

Wacholder, Sholom ;

Wijsman, Ellen M. ;

Winn, Deborah M. ;

Collins, Francis S. .

NATURE, 2007, 447 (7145) :655-660

[9] The DISC locus in psychiatric illness [J].

Chubb, J. E. ;

Bradshaw, N. J. ;

Soares, D. C. ;

Porteous, D. J. ;

Millar, J. K. .

MOLECULAR PSYCHIATRY, 2008, 13 (01) :36-64

[10] Behavioral phenotypes of Disc1 missense mutations in mice [J].

Clapcote, Steven J. ;

Lipina, Tatiana V. ;

Millar, J. Kirsty ;

Mackie, Shaun ;

Christie, Sheila ;

Ogawa, Fumiaki ;

Lerch, Jason P. ;

Trimble, Keith ;

Uchiyama, Masashi ;

Sakuraba, Yoshiyuki ;

Kaneda, Hideki ;

Shiroishi, Toshihiko ;

Houslay, Miles D. ;

Henkelman, R. Mark ;

Sled, John G. ;

Gondo, Yoichi ;

Porteous, David J. ;

Roder, John C. .

NEURON, 2007, 54 (03) :387-402

← 1 2 3 4 5 →