Monodisperse Gas-Filled Microparticles from Reactions in Double Emulsions

被引：38

作者：

Duncanson, Wynter J. ^{[2
]}

Abbaspourrad, Alireza ^{[2
]}

Shum, Ho Cheung

Kim, Shin-Hyun ^{[2
]}

Adams, Laura L. A. ^{[2
]}

Weitz, David A. ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

[2] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

LANGMUIR | 2012年 / 28卷 / 17期

关键词：

ULTRASOUND CONTRAST AGENTS; GENE DELIVERY-SYSTEM; MICROFLUIDIC FABRICATION; MICROBUBBLES; MICROSPHERES; SURFACTANTS; DRUG;

D O I：

10.1021/la300915p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present a strategy for preparing size-controlled gas-filled microparticles using two aqueous components that chemically react to produce the gas. We use a dual-bore microfluidic device to isolate the reactants of two gas-producing reactions until they are encapsulated in the outer droplet. The reactants in the monodisperse droplets merge and produce the gas bubbles, which are stabilized with a surfactant and form the core of the microparticles. The number and size of the generated gas bubbles are governed by the gas-forming reaction used. Our versatile strategy can be applied to a wide range of gas-producing reactions.

引用

页码：6742 / 6745

页数：4

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