What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from theENIGMABipolar Disorder Working Group

被引：91

作者：

Ching, Christopher R. K. ^{[1
]}

Hibar, Derrek P. ^{[2
]}

Gurholt, Tiril P. ^{[3
,4
]}

Nunes, Abraham ^{[5
,6
]}

Thomopoulos, Sophia I. ^{[1
]}

Abe, Christoph ^{[6
,7
]}

Agartz, Ingrid ^{[3
,8
,9
]}

Brouwer, Rachel M. ^{[10
]}

Cannon, Dara M. ^{[11
]}

de Zwarte, Sonja M. C. ^{[10
]}

Eyler, Lisa T. ^{[12
,13
]}

Favre, Pauline ^{[14
,15
]}

Hajek, Tomas ^{[4
,16
]}

Haukvik, Unn K. ^{[4
,17
]}

Houenou, Josselin ^{[14
,15
,18
]}

Landen, Mikael ^{[19
,20
]}

Lett, Tristram A. ^{[21
,22
]}

McDonald, Colm ^{[10
]}

Nabulsi, Leila ^{[1
,10
]}

Patel, Yash ^{[23
]}

Pauling, Melissa E. ^{[13
,14
]}

Paus, Tomas ^{[23
,24
,25
]}

Radua, Joaquim ^{[8
,26
,27
,28
]}

Soeiro-de-Souza, Marcio G. ^{[29
]}

Tronchin, Giulia ^{[10
]}

van Haren, Neeltje E. M. ^{[30
]}

Vieta, Eduard ^{[26
,31
]}

Walter, Henrik ^{[21
]}

Zeng, Ling-Li ^{[1
,32
]}

Alda, Martin ^{[4
]}

Almeida, Jorge ^{[33
]}

Alnaes, Dag ^{[3
]}

Alonso-Lana, Silvia ^{[3
,35
]}

Altimus, Cara ^{[36
]}

Bauer, Michael ^{[37
]}

Baune, Bernhard T. ^{[38
,39
,40
]}

Bearden, Carrie E. ^{[41
,42
]}

Bellani, Marcella ^{[43
]}

Benedetti, Francesco ^{[44
,45
]}

Berk, Michael ^{[46
,47
]}

Bilderbeck, Amy C. ^{[48
,49
,50
]}

Blumberg, Hilary P. ^{[51
]}

Boen, Erlend ^{[44
,52
]}

Bollettini, Irene ^{[45
]}

del Mar Bonnin, Caterina ^{[26
,31
]}

Brambilla, Paolo ^{[53
,54
]}

Canales-Rodriguez, Erick J. ^{[34
,35
,55
,56
]}

Caseras, Xavier ^{[57
]}

Dandash, Orwa ^{[58
,59
,60
]}

Dannlowski, Udo ^{[38
]}

机构：

[1] Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Keck Sch Med, Imaging Genet Ctr, Los Angeles, CA 90007 USA

[2] Genentech Inc, San Francisco, CA 94080 USA

[3] Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway

[4] Oslo Univ Hosp, Div Mental Hlth & Addicit, Oslo, Norway

[5] Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada

[6] Dalhousie Univ, Fac Comp Sci, Halifax, NS, Canada

[7] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[8] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

[9] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden

[10] Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr, Dept Psychiat, Utrecht, Netherlands

[11] Natl Univ Ireland Galway, NCBES Galway Neurosci Ctr, Coll Med Nursing & Hlth Sci,Clin Neuroimaging Lab, Ctr Neuroimaging & Cognit Genom NICOG, Galway, Ireland

[12] Univ Calif, Dept Psychiat, La Jolla, CA USA

[13] VA San Diego Healthcare, Desert Pacific MIRECC, San Diego, CA USA

[14] INSERM, U955, Team 15 Translat Neuropsychiat, Creteil, France

[15] CEA Paris Saclay, Team UNIACT, Neurospin, Gif Sur Yvette, France

[16] Natl Inst Mental Hlth, Klecany, Czech Republic

[17] Oslo Univ Hosp, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway

[18] Mondor Univ Hosp, AP HP, DMU IMPACT, Creteil, France

[19] Univ Gothenburg, Dept Neurosci & Physiol, Gothenburg, Sweden

[20] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[21] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

[22] Charite Univ Med Berlin, Dept Neurol Expt Neurol, Berlin, Germany

[23] Holland Bloorview Kids Rehabil Hosp, Bloorview Res Inst, Toronto, ON, Canada

[24] Univ Toronto, Dept Psychol, Toronto, ON, Canada

[25] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[26] Ctr Invest Biomed Red Salud Mental CIBERSAM, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

[27] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England

[28] Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden

[29] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Mood Disorders Unit GRUDA, Sao Paulo, SP, Brazil

[30] Erasmus MC, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands

[31] Univ Barcelona, Inst Neurosci, Barcelona Bipolar Disorders & Depress Unit, Hosp Clin, Barcelona, Spain

[32] Natl Univ Def Technol, Coll Intelligence Sci & Technol, Changsha, Peoples R China

[33] Univ Texas Austin, Dell Med Sch, Austin, TX 78712 USA

[34] FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain

[35] CIBERSAM, Madrid, Spain

[36] Milken Inst, Ctr Strateg Philanthropy, Washington, DC USA

[37] Tech Univ Dresden, Fac Med, Dept Psychiat & Psychotherapy, Dresden, Germany

[38] Univ Munster, Dept Psychiat, Munster, Germany

[39] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia

[40] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[41] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA

[42] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA

[43] Univ Verona, Dept Neurosci Biomed & Movement Sci, Sect Psychiat, Verona, Italy

[44] Univ Vita Salute San Raffaele, Milan, Italy

[45] IRCCS San Raffaele Sci Inst, Psychiat & Psychobiol, Div Neurosci, Milan, Italy

[46] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy

[47] Deakin Univ, IMPACT Inst, Inst Mental & Phys Hlth & Clin Translat, Sch Med,Barwon Hlth, Geelong, Vic, Australia

[48] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Natl Ctr Excellence Youth Mental Hlth, Ctr Youth Mental Hlth, Melbourne, Vic, Australia

[49] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia

[50] P1vital Ltd, Wallingford, Oxon, England

来源：

HUMAN BRAIN MAPPING | 2022年 / 43卷 / 01期

基金：

英国医学研究理事会; 欧盟第七框架计划; 英国惠康基金; 加拿大自然科学与工程研究理事会; 加拿大健康研究院; 巴西圣保罗研究基金会; 澳大利亚国家健康与医学研究理事会; 日本学术振兴会; 瑞典研究理事会; 欧洲研究理事会; 新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

bipolar disorder; cortical surface area; cortical thickness; ENIGMA; mega-analysis; meta-analysis; MRI; neuroimaging; psychiatry; volume; MAJOR PSYCHIATRIC-DISORDERS; GRAY-MATTER VOLUME; HUMAN BRAIN; SCHIZOAFFECTIVE DISORDER; COGNITIVE IMPAIRMENT; HIPPOCAMPAL VOLUMES; PSYCHOTIC FEATURES; CORTICAL THICKNESS; DIABETES-MELLITUS; SPECTRUM DISORDER;

D O I：

10.1002/hbm.25098

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.

引用

页码：56 / 82

页数：27

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