Biosynthesis and processing of pro CCK: recent progress and future challenges

被引：45

作者：

Beinfeld, MC ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA

来源：

LIFE SCIENCES | 2003年 / 72卷 / 07期

关键词：

CCK; PC1; PC2; PC5; post-translational modifications of proteins; tyrosine sulfation; amidation; carboxypeptidase E;

D O I：

10.1016/S0024-3205(02)02330-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pro Cholecystokinin (CCK) like other prohormones that pass through the regulated secretory pathway, undergoes a number of post-translational modifications during its biosynthesis including tyrosine sulfation, endoproteolytic cleavages, trimming by carboxypeptidase and c-terminal amidation. This minireview summarizes what is known about this process, what specific enzymes are involved in endocrine and neuronal tumor cells and in mutant and knockout mouse strains. It also points out the major challenges that remain for future research. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：747 / 757

页数：11

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