Synthesis of substituted 3-iodopyrroles by electrophilic cyclization of propargylic aziridines

被引：20
作者：
Yoshida, Masahiro [1 ]
Al-Amin, Mohammad [1 ]
Shishido, Kozo [1 ]
机构：
[1] Univ Tokushima, Grad Sch Pharmaceut Sci, Tokushima 7708505, Japan
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 46期
基金：
日本学术振兴会;
关键词：
STEREOSELECTIVE-SYNTHESIS; ISOQUINOLINES; DERIVATIVES; PYRROLE; FURANS; ALKYNES;
D O I：
10.1016/j.tetlet.2009.09.004
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The electrophilic cyclization of propargylic aziridines is described. 3-Iodopyrroles having a variety of substituents were conveniently synthesized by the reaction of propargylic aziridines with iodine. The resulting substituted 3-iodopyrrole was further functionalized to the tri-substituted pyrroles with high efficiency. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6268 / 6270
页数：3
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