The Use of Intravenous Aminobisphosphonates for the Treatment of Paget's Disease of Bone

被引：15
作者：
Gennari, Luigi [1 ]
Merlotti, Daniela
Mossetti, Giuseppe
Rendina, Domenico
De Paola, Vincenzo
Martini, Giuseppe
Nuti, Ranuccio
机构：
[1] Univ Siena, Dept Internal Med Endocrine Metab Sci & Biochem, I-53100 Siena, Italy
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 09期
关键词：
Paget's disease of bone; bone turnover; bisphosphonates; zoledronic acid; pamidronate; neridronate; ZOLEDRONIC ACID; SINGLE INFUSION; AMINOHEXANE DIPHOSPHONATE; MINERALIZATION DEFECTS; ACQUIRED-RESISTANCE; PAMIDRONATE THERAPY; NATURAL-HISTORY; DOUBLE-BLIND; BISPHOSPHONATES; NERIDRONATE;
D O I：
10.2174/138955709788922683
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Paget's disease of bone is a focal skeletal disorder characterized by the formation of structurally abnormal bone, deformity and other complications leading to significant disability and bone pain. Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this disorder.
引用
收藏
页码：1052 / 1063
页数：12
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