Synthesis of (-)-mellein, (+)-ramulosin, and related natural products

被引：48

作者：

Islam, Md. Sadequl ^{[1
]}

Ishigami, Ken ^{[1
]}

Watanabe, Hidenori ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan

来源：

TETRAHEDRON | 2007年 / 63卷 / 05期

关键词：

PAPYRACEUM KARST KARST; NERVE GROWTH-FACTOR; ANTIMICROBIAL ACTIVITIES; ISOCOUMARIN DERIVATIVES; ASYMMETRIC-SYNTHESIS; FACILE SYNTHESIS; DIHYDROISOCOUMARINS; METABOLITES; MELLEIN; RAMULOSIN;

D O I：

10.1016/j.tet.2006.11.068

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(-)-Mellein, (+)-ramulosin, (-)-O-methylmellein, (-)-6-hydroxymellein, (-)-6-methoxymellein, and (+)-6-hydroxyramulosin were synthesized as optically active forms using one-pot esterification-Michael addition-aldol reaction of delta-hydroxy-alpha,beta-unsaturated aldehyde and diketene as a key step. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1074 / 1079

页数：6