p53 and the Viral Connection: Back into the Future

被引：67

作者：

Aloni-Grinstein, Ronit ^{[1
,2
]}

Charni-Natan, Meital ^{[1
]}

Solomon, Hilla ^{[1
]}

Rotter, Varda ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel

[2] Israel Inst Biol Res, Dept Biochem & Mol Genet, Box 19, IL-74100 Ness Ziona, Israel

来源：

CANCERS | 2018年 / 10卷 / 06期

基金：

以色列科学基金会;

关键词：

virus; p53; cancer; SV40; papilloma; zika; influenza; HIV-1; HSV-1; vaccinia; INFLUENZA-A VIRUS; LARGE-T-ANTIGEN; LARGE TUMOR-ANTIGEN; CELL-CYCLE ARREST; HUMAN-PAPILLOMAVIRUS; ZIKA VIRUS; PROTEIN; SUPPRESSOR; INFECTION; APOPTOSIS;

D O I：

10.3390/cancers10060178

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as well. These include the influenza virus, smallpox and vaccinia viruses, the Zika virus, West Nile virus, Japanese encephalitis virus, Human Immunodeficiency Virus Type 1, Human herpes simplex virus-1, and more. Viruses have learned to manipulate WTp53 through different strategies to improve their replication and spreading in a stage-specific, bidirectional way. While some viruses require active WTp53 for efficient viral replication, others require reduction/inhibition of WTp53 activity. A better understanding of WTp53 functionality in viral life may offer new future clinical approaches, based on WTp53 manipulation, for viral infections.

引用

页数：11

共 77 条

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