From words to literature in structural proteomics

被引：344
作者：
Sali, A [1 ]
Glaeser, R
Earnest, T
Baumeister, W
机构：
[1] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Calif Inst Quantitat Biomed Res, San Francisco, CA 94143 USA
[4] Univ Calif Berkeley, Dept Mol & Cell Biol, Stanley Donner ASU, Berkeley, CA 94720 USA
[5] Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley Ctr Struct Biol, Berkeley, CA 94720 USA
[6] Max Planck Inst Biochem, Dept Biol Struct, D-82152 Martinsried, Germany
来源：
NATURE | 2003年 / 422卷 / 6928期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nature01513
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Technical advances on several frontiers have expanded the applicability of existing methods in structural biology and helped close the resolution gaps between them. As a result, we are now poised to integrate structural information gathered at multiple levels of the biological hierarchy - from atoms to cells - into a common framework. The goal is a comprehensive description of the multitude of interactions between molecular entities, which in turn is a prerequisite for the discovery of general structural principles that underlie all cellular processes.
引用
收藏
页码：216 / 225
页数：10
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