Neurodevelopmental origins of depressive disorders

被引：151
作者：
Ansorge, Mark S.
Hen, Rene
Gingrich, Jay A.
机构：
[1] Columbia Univ Coll Phys & Surg, Dept Psychiat, Sackler Inst Labs, New York, NY 10032 USA
[2] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[3] Columbia Univ Coll Phys & Surg, Dept Psychiat, Ctr Neurobiol & Behav, New York, NY 10032 USA
[4] Columbia Univ Coll Phys & Surg, Dept Pharmacol, Ctr Neurobiol & Behav, New York, NY 10032 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2007年 / 7卷 / 01期
关键词：
SEROTONIN TRANSPORTER GENE; RECEPTOR-ALPHA EXPRESSION; IMPAIRED STRESS-RESPONSE; ANXIETY-RELATED BEHAVIOR; GROWTH CONE MOTILITY; DORSAL RAPHE NUCLEUS; MATERNAL-CARE; TRYPTOPHAN-HYDROXYLASE; HIPPOCAMPAL NEUROGENESIS; NEUROTROPHIC FACTOR;
D O I：
10.1016/j.coph.2006.11.006
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Depression is a common and devastating neuropsychiatric disorder, and a better understanding of its pathophysiology is needed to improve diagnosis, treatment and prevention. By considering the developmental dimensions of genetic and environmental factors, new insights have been found into the etiology and pathophysiology of depression. Specifically, we begin to understand how certain vulnerability factors affect the maturation of brain circuits involved in emotional function to increase the risk for depressive disorders later in life. These new findings might help us to better categorize and manage this complex disease.
引用
收藏
页码：8 / 17
页数：10
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