Investigation of the protective and therapeutic effects of β-aminoisobutyric acid (BAIBA) and Thymoquinone in the diabetic nephropathy

被引：11

作者：

Aktas, Ibrahim ^{[1
]}

Gur, Fatih Mehmet ^{[2
]}

机构：

[1] Adiyaman Univ, Vocat Sch Hlth Serv, Dept Pharmacol, Adiyaman, Turkey

[2] Nigde Omer Halisdemir Univ, Fac Med, Dept Histol & Embryol, Nigde, Turkey

来源：

BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2021年 / 20卷 / 03期

关键词：

beta-aminoisobutyric acid; Diabetic nephropathy; Rat; Streptozotocin; Thymoquinone; NIGELLA-SATIVA OIL; OXIDATIVE STRESS; RENAL-FUNCTION; LIVER-DISEASE; RAT MODEL; KIDNEY; TYPE-1; INFLAMMATION; APOPTOSIS; PREVENTS;

D O I：

10.37360/blacpma.21.20.3.22

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

In this study, against streptozotocin (STZ) induced diapetic nephropathy (DN); it is aimed to investigate the use of thymoquinone (TQ) and beta-aminoisobutyric acid (BAIBA) and to compare the effects of these agents. With random selection of 35 male rats, five groups (seven rats in each group) were constituted as follows: Control, STZ, STZ + TQ, STZ + BAIBA, STZ + TQ + BAIBA. In the STZ group; body weight, glutathione (GSH) and insulin levels decreased, relative kidney v.:iglu, malondialdehyde (MDA), glucose, blood urea nitrogen (BUN) and creatinine (Cr) levels were increased. Also, in kidney tissue; histopathological changes (such as thickening of the capsular, glomerular and tubular basement membranes, increased mesangial matrix amount, increased cytoplasmic vacuolization in some of the tubular epithelial cells, increased tumor necrosis factor-alpha (TNF-alpha) expression, and inflammatory cell infiltrations in interstitial tissue) were detected. It was observed that these changes occurring after diabetes mellitus (DM) reversed significantly in TQ, BAIBA and TQ + BAIBA groups.

引用

页码：303 / 314

页数：12

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