Investigation of the protective and therapeutic effects of β-aminoisobutyric acid (BAIBA) and Thymoquinone in the diabetic nephropathy

被引：11
作者：
Aktas, Ibrahim [1 ]
Gur, Fatih Mehmet [2 ]
机构：
[1] Adiyaman Univ, Vocat Sch Hlth Serv, Dept Pharmacol, Adiyaman, Turkey
[2] Nigde Omer Halisdemir Univ, Fac Med, Dept Histol & Embryol, Nigde, Turkey
来源：
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2021年 / 20卷 / 03期
关键词：
beta-aminoisobutyric acid; Diabetic nephropathy; Rat; Streptozotocin; Thymoquinone; NIGELLA-SATIVA OIL; OXIDATIVE STRESS; RENAL-FUNCTION; LIVER-DISEASE; RAT MODEL; KIDNEY; TYPE-1; INFLAMMATION; APOPTOSIS; PREVENTS;
D O I：
10.37360/blacpma.21.20.3.22
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
In this study, against streptozotocin (STZ) induced diapetic nephropathy (DN); it is aimed to investigate the use of thymoquinone (TQ) and beta-aminoisobutyric acid (BAIBA) and to compare the effects of these agents. With random selection of 35 male rats, five groups (seven rats in each group) were constituted as follows: Control, STZ, STZ + TQ, STZ + BAIBA, STZ + TQ + BAIBA. In the STZ group; body weight, glutathione (GSH) and insulin levels decreased, relative kidney v.:iglu, malondialdehyde (MDA), glucose, blood urea nitrogen (BUN) and creatinine (Cr) levels were increased. Also, in kidney tissue; histopathological changes (such as thickening of the capsular, glomerular and tubular basement membranes, increased mesangial matrix amount, increased cytoplasmic vacuolization in some of the tubular epithelial cells, increased tumor necrosis factor-alpha (TNF-alpha) expression, and inflammatory cell infiltrations in interstitial tissue) were detected. It was observed that these changes occurring after diabetes mellitus (DM) reversed significantly in TQ, BAIBA and TQ + BAIBA groups.
引用
收藏
页码：303 / 314
页数：12
相关论文
共 58 条
[1]   Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice [J].
Abdel-Fattah, AFM ;
Matsumoto, K ;
Watanabe, H .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 400 (01) :89-97
[2]   Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats [J].
Abdelrazek, Heba M. A. ;
Kilany, Omnia E. ;
Muhammad, Muhammad A. A. ;
Tag, Hend M. ;
Abdelazim, Aaser M. .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
[3]  
Al-Trad B, 2016, EUR REV MED PHARMACO, V20, P2680
[4]  
[Anonymous], 2012, WORLD ACAD SCI ENG T
[5]   Thymoquinone alleviates nonalcoholic fatty liver disease in rats via suppression of oxidative stress, inflammation, apoptosis [J].
Awad, Azza S. M. ;
Abd Al Haleem, Ekram N. ;
El-Bakly, Wesam M. ;
Sherief, Mohie A. .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2016, 389 (04) :381-391
[6]  
Bashandy SAE., 2015, AM J PHYTOMEDICINE C, V3, P287
[7]   Streptozotocin produces oxidative stress, inflammation and decreases BDNF concentrations to induce apoptosis of RIN5F cells and type 2 diabetes mellitus in Wistar rats [J].
Bathina, Siresha ;
Srinivas, Nanduri ;
Das, Undurti N. .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 486 (02) :406-413
[8]   The Effects of Soy Milk Enriched with Lactobacillus casei and Omega-3 on the Tibia and L5 Vertebra in Diabetic Rats: a Stereological Study [J].
Bayat, Maryam ;
Dabbaghmanesh, Mohammad Hossein ;
Koohpeyma, Farhad ;
Mahmoodi, Marzieh ;
Montazeri-Najafabady, Nima ;
Bakhshayeshkaram, Marzieh .
PROBIOTICS AND ANTIMICROBIAL PROTEINS, 2019, 11 (04) :1172-1181
[9]   β-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency [J].
Begriche, Karima ;
Massart, Julie ;
Abbey-Toby, Adje ;
Igoudjil, Anissa ;
Letteon, Philippe ;
Fromenty, Bernard .
OBESITY, 2008, 16 (09) :2053-2067
[10]   Increased susceptibility to streptozotocin-induced β-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice [J].
Cardinal, JW ;
Margison, GP ;
Mynett, KJ ;
Yates, AP ;
Cameron, DP ;
Elder, RH .
MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (16) :5605-5613
123456