Intramolecular functional group differentiation as a strategy for the synthesis of bridged bicyclic β-amino acids

被引：11

作者：

Tymtsunik, Andriy V. ^{[1
,2
]}

Kokhan, Serhii O. ^{[1
,2
]}

Ivon, Yevhen M. ^{[1
,2
]}

Komarov, Igor V. ^{[1
,2
]}

Grygorenko, Oleksandr O. ^{[1
]}

机构：

[1] Natl Taras Shevchenko Univ Kyiv, Volodymyrska St 64, UA-01601 Kiev, Ukraine

[2] Enamine Ltd, Alexandra Matrosova St 23, UA-01103 Kiev, Ukraine

来源：

RSC ADVANCES | 2016年 / 6卷 / 27期

关键词：

DIVERSITY-ORIENTED SYNTHESIS; PEPTIDES;

D O I：

10.1039/c6ra01548d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Differentiation of identical electrophilic functional groups (carboxylates) by a strategically placed internal nucleophile (an amino group) in cyclic precursors was used as a key general approach to functionalized azabicyclic scaffolds. The utility of the method was demonstrated by the synthesis of three bicyclic beta-amino acids (analogues of nipecotic acid), which were prepared in good yields and on a relatively large scale.

引用

页码：22737 / 22748

页数：12

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