Kinetic study of enantioselective esterification of ketoprofen with n-propanol catalysed by an lipase in an organic medium

被引：35

作者：

Duan, G

Ching, CB

Lim, E

Ang, CH

机构：

[1] Department of Chemical Engineering, National University of Singapore, Singapore 119260

来源：

BIOTECHNOLOGY LETTERS | 1997年 / 19卷 / 11期

关键词：

D O I：

10.1023/A:1018420022398

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A kinetic study of an immobilised lipase esterification reaction in dipropyl ether for resolution of ketoprofen indicated a Bi Bi Ping Pong mechanism with dead-end inhibition of the alcohol was occurring for both enantiomers and this is was confirmed experimentally. Parameters in the kinetic equation and reaction activation energies for the two enantiomers were determined by non-linear regression.

引用

页码：1051 / 1055

页数：5

共 8 条

[1]

Bailey J.E., 1986, BIOCH ENG FUNDAMENTA, P212

[2]

Cabral J.M.S., 1994, APPL BIOCATALYSIS

[3] GENERAL-ASPECTS AND OPTIMIZATION OF ENANTIOSELECTIVE BIOCATALYSIS IN ORGANIC-SOLVENTS - THE USE OF LIPASES [J].