Intrinsically Disordered Proteins Adaptively Reorganize Cellular Matter During Stress

被引：18

作者：

Chavali, Sreenivas ^{[1
]}

Gunnarsson, Alexander ^{[1
]}

Babu, M. Madan ^{[1
]}

机构：

[1] MRC, Lab Mol Biol, Francis Crick Ave, Cambridge, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2017年 / 42卷 / 06期

关键词：

PHASE-SEPARATION; GRANULES;

D O I：

10.1016/j.tibs.2017.04.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intrinsically disordered proteins (IDPs) can protect cells from diverse stresses by forming higher order assemblies such as reversible aggregates or granules. Recently, Boothby et al. show that IDPs protect tardigrades against desiccation by forming a glass-like amorphous matrix, highlighting that material properties of disordered proteins can confer adaptation during stress.

引用

页码：410 / 412

页数：4

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