Radiation Formation of Psyllium Cross-Linked Poly( hydroxyethylmethacrylate)-co-poly(acrylamide) Based Sterile Hydrogels for Drug Delivery Applications

Both, gel forming dietary fiber psyllium and antibiotic drug ciprofloxacin, have pharmacological importance in case of gastrointestinal tract problems. Hence, in the present work, an attempt has been made to design the ciprofloxacin loaded psyllium cross-linked poly(hydroxyethylmethacrylate-co-acrylamide) based sterile hydrogels for drug delivery application in gastrointestinal tract problems diverticulitis which occur due to constipation and microbial infestation. These polymers have been characterized by SEM, cryo-SEM, EDAX, FTIR, TGA/ DTA/DTG, XRD. The swelling of the hydrogels and release dynamics of drug from the hydrogels have been studied for the evaluation of the swelling and drug release mechanism respectively. The release of the drug from the hydrogels occurred through non-Fickian diffusion mechanism in slow manner. Overall, the ciprofloxacin loaded psyllium based drug delivery system may act with enhanced potential to cure the diverticulitis.