HLA-A, -B, -C, -DRB1 allele and haplotype frequencies in an African American population

被引:45
作者
Tu, B.
Mack, S. J.
Lazaro, A.
Lancaster, A.
Thomson, G.
Cao, K.
Chen, M.
Ling, G.
Hartzman, R.
Ng, J.
Hurley, C. K.
机构
[1] Georgetown Univ, CW Bill Young Marrow Donor Recruitment & Res Prog, Dept Pediat, Washington, DC 20057 USA
[2] Georgetown Univ, Dept Oncol, Washington, DC 20057 USA
[3] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
[4] Roche Mol Syst, Alameda, CA USA
[5] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA
[6] Naval Med Res Ctr, CW Bill Young Marrow Donor Program, Rockville, MD USA
来源
TISSUE ANTIGENS | 2007年 / 69卷 / 01期
关键词
human leukocyte antigen; population study;
D O I
10.1111/j.1399-0039.2006.00728.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Sequence-based typing was used to identify human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 alleles from 564 consecutively recruited African American volunteers for an unrelated hematopoietic stem cell registry. The number of known alleles identified at each locus was 42 for HLA-A, HLA-B 67, HLA-C 33, and HLA-DRB1 44. Six novel alleles (A*260104, A*7411, Cw*0813, Cw*1608, Cw*1704, and DRB1*130502) not observed in the initial sequence-specific oligonucleotide probe testing were characterized. The action of balancing selection, shaping more 'even' than expected allele frequency distributions, was inferred for all four loci and significantly so for the HLA-A and DRB1 loci. Two-, three-, and four-locus haplotypes were estimated using the expectation maximization algorithm. Comparisons with other populations from Africa and Europe suggest that the degree of European admixture in the African American population described here is lower than that in other African American populations previously reported, although HLA-A:B haplotype frequencies similar to those in previous studies of African American individuals were also noted.
引用
收藏
页码:73 / 85
页数:13
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