Advances in Biomaterials and Technologies for Vascular Embolization

被引：245

作者：

Hu, Jingjie ^{[1
]}

Albadawi, Hassan ^{[1
]}

Chong, Brian W. ^{[2
,3
]}

Deipolyi, Amy R. ^{[4
]}

Sheth, Rahul A. ^{[5
]}

Khademhosseini, Ali ^{[6
]}

Oklu, Rahmi ^{[1
]}

机构：

[1] Mayo Clin, Minimally Invas Therapeut Lab, Div Vasc & Intervent Radiol, 13400 East Shea Blvd, Scottsdale, AZ 85259 USA

[2] Mayo Clin, Dept Radiol, 13400 East Shea Blvd, Scottsdale, AZ 85259 USA

[3] Mayo Clin, Dept Neurol Surg, 13400 East Shea Blvd, Scottsdale, AZ 85259 USA

[4] Mem Sloan Kettering Canc Ctr, Weill Cornell Med Ctr, Dept Intervent Radiol, 1275 York Ave, New York, NY 10065 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Intervent Radiol, Houston, TX 77054 USA

[6] Univ Calif Los Angeles, Calif Nanosyst Inst, Ctr Minimally Invas Therapeut, Dept Bioengn,Dept Radiol Sci,Dept Chem & Biomol E, 410 Westwood Plaza, Los Angeles, CA 90095 USA

来源：

ADVANCED MATERIALS | 2019年 / 31卷 / 33期

基金：

美国国家卫生研究院;

关键词：

catheter-based delivery; embolic agents; interventional radiology; minimally invasive surgery; vascular embolization; DRUG-ELUTING BEADS; UTERINE ARTERY EMBOLIZATION; CEREBRAL ARTERIOVENOUS-MALFORMATIONS; IRON-OXIDE NANOPARTICLES; LIQUID EMBOLIC AGENT; MEMORY POLYMER FOAM; IN-VIVO EVALUATION; HYDROPHOBIC INJECTABLE LIQUID; GELATIN SPONGE PARTICLES; CALCIUM ALGINATE GEL;

D O I：

10.1002/adma.201901071

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Minimally invasive transcatheter embolization is a common nonsurgical procedure in interventional radiology used for the deliberate occlusion of blood vessels for the treatment of diseased or injured vasculature. A wide variety of embolic agents including metallic coils, calibrated microspheres, and liquids are available for clinical practice. Additionally, advances in biomaterials, such as shape-memory foams, biodegradable polymers, and in situ gelling solutions have led to the development of novel preclinical embolic agents. The aim here is to provide a comprehensive overview of current and emerging technologies in endovascular embolization with respect to devices, materials, mechanisms, and design guidelines. Limitations and challenges in embolic materials are also discussed to promote advancement in the field.

引用

页数：52

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