Protein aggregation as a paradigm of aging

被引：81
作者：
Lindner, Ariel B.
Demarez, Alice
机构：
[1] INSERM, U571, F-75015 Paris, France
[2] Paris Descartes Univ, F-75015 Paris, France
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2009年 / 1790卷 / 10期
关键词：
Chaperone; Protein misfolding; Protein aggregation; Asymmetry; Proteostasis; Aging network; UBIQUITIN-PROTEASOME SYSTEM; AMYLOID-BETA-PROTEIN; HEAT-SHOCK RESPONSE; METHIONINE-SULFOXIDE-REDUCTASE; CHAPERONE-MEDIATED AUTOPHAGY; NUCLEOTIDE EXCHANGE FACTOR; HSP90 MOLECULAR CHAPERONE; INCLUSION-BODY MYOSITIS; ALPHA-SYNUCLEIN; PARKINSONS-DISEASE;
D O I：
10.1016/j.bbagen.2009.06.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The process of physiological decline leading to death of the individual is driven by the deteriorating capacity to withstand extrinsic and intrinsic hazards, resulting in damage accumulation with age. The dynamic changes with time of the network governing the outcome of misfolded proteins, exemplifying as intrinsic hazards, is considered here as a paradigm of aging. The main features of the network, namely, the non-linear increase of damage and the presence of amplifying feedback loops within the system are presented through a survey of the different components of the network and related cellular processes in aging and disease. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：980 / 996
页数：17
相关论文
共 351 条
[1]   Neuroscience: THE PLAQUE PLAN [J].
Abbott, Alison .
NATURE, 2008, 456 (7219) :161-164
[2]   Senescence in a bacterium with asymmetric division [J].
Ackermann, M ;
Stearns, SC ;
Jenal, U .
SCIENCE, 2003, 300 (5627) :1920-1920
[3]   On the evolutionary origin of aging [J].
Ackermann, Martin ;
Chao, Lin ;
Bergstrom, Carl T. ;
Doebeli, Michael .
AGING CELL, 2007, 6 (02) :235-244
[4]   Asymmetric inheritance of oxidatively damaged proteins during cytokinesis [J].
Aguilaniu, H ;
Gustafsson, L ;
Rigoulet, M ;
Nyström, T .
SCIENCE, 2003, 299 (5613) :1751-1753
[5]  
AHLBERG J, 1982, LAB INVEST, V47, P523
[6]  
Alberti S, 2003, CELL STRESS CHAPERON, V8, P225, DOI 10.1379/1466-1268(2003)008<0225:BNEFOH>2.0.CO
[7]  
2
[8]   Selectivity and proofreading both contribute significantly to the fidelity of RNA polymerase III transcription [J].
Alic, Nazif ;
Ayoub, Nayla ;
Landrieux, Emilie ;
Favry, Emmanuel ;
Baudouin-Cornu, Peggy ;
Riva, Michel ;
Carles, Christophe .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (25) :10400-10405
[9]   2 NOVEL HEAT-SHOCK GENES ENCODING PROTEINS PRODUCED IN RESPONSE TO HETEROLOGOUS PROTEIN EXPRESSION IN ESCHERICHIA-COLI [J].
ALLEN, SP ;
POLAZZI, JO ;
GIERSE, JK ;
EASTON, AM .
JOURNAL OF BACTERIOLOGY, 1992, 174 (21) :6938-6947
[10]   Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementation [J].
Ambra, R ;
Mocchegiani, E ;
Giacconi, R ;
Canali, R ;
Rinna, A ;
Malavolta, M ;
Virgili, F .
EXPERIMENTAL GERONTOLOGY, 2004, 39 (10) :1475-1484
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