Neutrophils and COVID-19: The road so far

被引：112

作者：

Agra Cavalcante-Silva, Luiz Henrique ^{[1
]}

Madruga Carvalho, Deyse Cristina ^{[1
]}

Lima, Essia de Almeida ^{[1
]}

Galvao, Jose G. F. M. ^{[1
]}

de Franca da Silva, Juliane S. ^{[1
]}

de Sales-Neto, Jose Marreiro ^{[1
]}

Rodrigues-Mascarenhas, Sandra ^{[1
]}

机构：

[1] Univ Fed Paraiba UFPB, Lab Imunobiotecnol, Ctr Biotecnol, Joao Pessoa, Paraiba, Brazil

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2021年 / 90卷

关键词：

Inflammation; Chemokines; NETs; SARS-CoV2; EXTRACELLULAR TRAPS; SARS-CORONAVIRUS; LYMPHOCYTE RATIO; INFECTIONS; AUTOIMMUNE; PNEUMONIA; ELASTASE; IMMUNITY; NETOSIS;

D O I：

10.1016/j.intimp.2020.107233

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyper inflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19 immunopathogenesis (e.g., dysfunctional IFN response and myeloid inflammation). In this regard, neutrophils have been highlighted as essential effector cells in the development of COVID-19. This review summarized the significant finds about neutrophils and its effector mechanisms (e.g., neutrophils enzymes and cytokines, neutrophil extracellular traps) in COVID-19 so far.

引用

页数：7

共 50 条

[21] Venous Thromboembolism Complicated with COVID-19: What Do We Know So Far? [J].

Tal, Shir ;

Spectre, Galia ;

Kornowski, Ran ;

Perl, Leor .

ACTA HAEMATOLOGICA, 2020, 143 (05) :417-424

[22] COVID-19 Mechanisms in the Human Body-What We Know So Far [J].

Kumar, Ashutosh ;

Narayan, Ravi K. ;

Prasoon, Pranav ;

Kumari, Chiman ;

Kaur, Gurjot ;

Kumar, Santosh ;

Kulandhasamy, Maheswari ;

Sesham, Kishore ;

Pareek, Vikas ;

Faiq, Muneeb A. ;

Pandey, Sada N. ;

Singh, Himanshu N. ;

Kant, Kamla ;

Shekhawat, Prakash S. ;

Raza, Khursheed ;

Kumar, Sujeet .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[23] What we know so far: COVID-19 current clinical knowledge and research [J].

Lake, Mary A. .

CLINICAL MEDICINE, 2020, 20 (02) :124-127

[24] Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19 [J].

Tomar, Bhawna ;

Anders, Hans-Joachim ;

Desai, Jyaysi ;

Mulay, Shrikant R. .

CELLS, 2020, 9 (06)

[25] NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond [J].

Zhu, Yuanfeng ;

Chen, Xiaoli ;

Liu, Xin .

FRONTIERS IN IMMUNOLOGY, 2022, 13

[26] COVID-19 Hyperinflammation: What about Neutrophils [J].

Didangelos, Athanasios .

MSPHERE, 2020, 5 (03)

[27] COVID-19 vaccination: The road ahead [J].

Altmann, Daniel M. ;

Boyton, Rosemary J. .

SCIENCE, 2022, 375 (6585) :1127-1132

[28] Neutrophils and Lymphocytes Can Help Distinguish Asymptomatic COVID-19 From Moderate COVID-19 [J].

Gu, Xuefeng ;

Sha, Ling ;

Zhang, Shaofeng ;

Shen, Duo ;

Zhao, Wei ;

Yi, Yongxiang .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 11

[29] COVID-19, a far cry from the influenza [J].

Ma, Chunxiang ;

Zhang, Hu .

PRECISION CLINICAL MEDICINE, 2020, 3 (02) :100-103

[30] Pediatrics and COVID-19 [J].

Toptan, Tuna ;

Ciesek, Sandra ;

Hoehl, Sebastian .

CORONAVIRUS DISEASE - COVID-19, 2021, 1318 :197-208

← 1 2 3 4 5 →