Neutrophils and COVID-19: The road so far

被引：117

作者：

Agra Cavalcante-Silva, Luiz Henrique ^{[1
]}

Madruga Carvalho, Deyse Cristina ^{[1
]}

Lima, Essia de Almeida ^{[1
]}

Galvao, Jose G. F. M. ^{[1
]}

de Franca da Silva, Juliane S. ^{[1
]}

de Sales-Neto, Jose Marreiro ^{[1
]}

Rodrigues-Mascarenhas, Sandra ^{[1
]}

机构：

[1] Univ Fed Paraiba UFPB, Lab Imunobiotecnol, Ctr Biotecnol, Joao Pessoa, Paraiba, Brazil

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2021年 / 90卷

关键词：

Inflammation; Chemokines; NETs; SARS-CoV2; EXTRACELLULAR TRAPS; SARS-CORONAVIRUS; LYMPHOCYTE RATIO; INFECTIONS; AUTOIMMUNE; PNEUMONIA; ELASTASE; IMMUNITY; NETOSIS;

D O I：

10.1016/j.intimp.2020.107233

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyper inflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19 immunopathogenesis (e.g., dysfunctional IFN response and myeloid inflammation). In this regard, neutrophils have been highlighted as essential effector cells in the development of COVID-19. This review summarized the significant finds about neutrophils and its effector mechanisms (e.g., neutrophils enzymes and cytokines, neutrophil extracellular traps) in COVID-19 so far.

引用

页数：7

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