Neutrophils and COVID-19: The road so far

被引：112
|
作者：
Agra Cavalcante-Silva, Luiz Henrique [1 ]
Madruga Carvalho, Deyse Cristina [1 ]
Lima, Essia de Almeida [1 ]
Galvao, Jose G. F. M. [1 ]
de Franca da Silva, Juliane S. [1 ]
de Sales-Neto, Jose Marreiro [1 ]
Rodrigues-Mascarenhas, Sandra [1 ]
机构：
[1] Univ Fed Paraiba UFPB, Lab Imunobiotecnol, Ctr Biotecnol, Joao Pessoa, Paraiba, Brazil
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2021年 / 90卷
关键词：
Inflammation; Chemokines; NETs; SARS-CoV2; EXTRACELLULAR TRAPS; SARS-CORONAVIRUS; LYMPHOCYTE RATIO; INFECTIONS; AUTOIMMUNE; PNEUMONIA; ELASTASE; IMMUNITY; NETOSIS;
D O I：
10.1016/j.intimp.2020.107233
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyper inflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19 immunopathogenesis (e.g., dysfunctional IFN response and myeloid inflammation). In this regard, neutrophils have been highlighted as essential effector cells in the development of COVID-19. This review summarized the significant finds about neutrophils and its effector mechanisms (e.g., neutrophils enzymes and cytokines, neutrophil extracellular traps) in COVID-19 so far.
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页数：7
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