Neutrophils and COVID-19: The road so far

被引：112

作者：

Agra Cavalcante-Silva, Luiz Henrique ^{[1
]}

Madruga Carvalho, Deyse Cristina ^{[1
]}

Lima, Essia de Almeida ^{[1
]}

Galvao, Jose G. F. M. ^{[1
]}

de Franca da Silva, Juliane S. ^{[1
]}

de Sales-Neto, Jose Marreiro ^{[1
]}

Rodrigues-Mascarenhas, Sandra ^{[1
]}

机构：

[1] Univ Fed Paraiba UFPB, Lab Imunobiotecnol, Ctr Biotecnol, Joao Pessoa, Paraiba, Brazil

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2021年 / 90卷

关键词：

Inflammation; Chemokines; NETs; SARS-CoV2; EXTRACELLULAR TRAPS; SARS-CORONAVIRUS; LYMPHOCYTE RATIO; INFECTIONS; AUTOIMMUNE; PNEUMONIA; ELASTASE; IMMUNITY; NETOSIS;

D O I：

10.1016/j.intimp.2020.107233

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyper inflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19 immunopathogenesis (e.g., dysfunctional IFN response and myeloid inflammation). In this regard, neutrophils have been highlighted as essential effector cells in the development of COVID-19. This review summarized the significant finds about neutrophils and its effector mechanisms (e.g., neutrophils enzymes and cytokines, neutrophil extracellular traps) in COVID-19 so far.

引用

页数：7

共 118 条

[1] Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19? [J].

Abouhashem, Ahmed S. ;

Singh, Kanhaiya ;

Azzazy, Hassan M. E. ;

Sen, Chandan K. .

ANTIOXIDANTS & REDOX SIGNALING, 2020, 33 (02) :59-65

[2] Neutrophils and acute lung injury [J].

Abraham, E .

CRITICAL CARE MEDICINE, 2003, 31 (04) :S195-S199

[3] Gastrointestinal and Liver Manifestations of COVID-19 [J].

Agarwal, Amol ;

Chen, Alan ;

Ravindran, Nishal ;

To, Chau ;

Thuluvath, Paul J. .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, 2020, 10 (03) :263-265

[4] Clinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome [J].

Aikawa, Naoki ;

Kawasaki, Yasushi .

THERAPEUTICS AND CLINICAL RISK MANAGEMENT, 2014, 10 :621-629

[5] The proximal origin of SARS-CoV-2 [J].

Andersen, Kristian G. ;

Rambaut, Andrew ;

Lipkin, W. Ian ;

Holmes, Edward C. ;

Garry, Robert F. .

NATURE MEDICINE, 2020, 26 (04) :450-452

[6] Average Values and Racial Differences of Neutrophil Lymphocyte Ratio among a Nationally Representative Sample of United States Subjects [J].

Azab, Basem ;

Camacho-Rivera, Marlene ;

Taioli, Emanuela .

PLOS ONE, 2014, 9 (11)

[7] Targeting potential drivers of COVID-19: Neutrophil extracellular traps [J].

Barnes, Betsy J. ;

Adrover, Jose M. ;

Baxter-Stoltzfus, Amelia ;

Borczuk, Alain ;

Cools-Lartigue, Jonathan ;

Crawford, James M. ;

Dassler-Plenker, Juliane ;

Guerci, Philippe ;

Huynh, Caroline ;

Knight, Jason S. ;

Loda, Massimo ;

Looney, Mark R. ;

McAllister, Florencia ;

Rayes, Roni ;

Renaud, Stephane ;

Rousseau, Simon ;

Salvatore, Steven ;

Schwartz, Robert E. ;

Spicer, Jonathan D. ;

Yost, Christian C. ;

Weber, Andrew ;

Zuo, Yu ;

Egeblad, Mikala .

JOURNAL OF EXPERIMENTAL MEDICINE, 2020, 217 (06)

[8] Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 [J].

Blanco-Melo, Daniel ;

Nilsson-Payant, Benjamin E. ;

Liu, Wen-Chun ;

Uhl, Skyler ;

Hoagland, Daisy ;

Moller, Rasmus ;

Jordan, Tristan X. ;

Oishi, Kohei ;

Panis, Maryline ;

Sachs, David ;

Wang, Taia T. ;

Schwartz, Robert E. ;

Lim, Jean K. ;

Albrecht, Randy A. ;

tenOever, Benjamin R. .

CELL, 2020, 181 (05) :1036-+

[9] Neutrophil extracellular traps kill bacteria [J].

Brinkmann, V ;

Reichard, U ;

Goosmann, C ;

Fauler, B ;

Uhlemann, Y ;

Weiss, DS ;

Weinrauch, Y ;

Zychlinsky, A .

SCIENCE, 2004, 303 (5663) :1532-1535

[10] The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities [J].

Buja, Louis Maximilian ;

Wolf, Dwayne A. ;

Zhao, Bihong ;

Akkanti, Bindu ;

McDonald, Michelle ;

Lelenwa, Laura ;

Reilly, Noah ;

Ottaviani, Giulia ;

Elghetany, M. Tarek ;

Trujillo, Daniel Ocazionez ;

Aisenberg, Gabriel M. ;

Madjid, Mohammad ;

Kar, Biswajit .

CARDIOVASCULAR PATHOLOGY, 2020, 48

← 1 2 3 4 5 6 7 8 9 10 →