Imaging features that distinguish pure ductal carcinoma in situ (DCIS) from DCIS with microinvasion

被引：14

作者：

Wang, Hongli ^{[1
,2
]}

Lin, Jinjiang ^{[3
]}

Lai, Jianguo ^{[1
,2
]}

Tan, Cui ^{[1
,2
]}

Yang, Yaping ^{[1
,2
]}

Gu, Ran ^{[1
,2
]}

Jiang, Xiaofang ^{[1
,2
]}

Liu, Fengtao ^{[1
,2
]}

Hu, Yue ^{[1
,2
]}

Su, Fengxi ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Breast Tumor Ctr, 33 Yingfeng Rd, Guangzhou 510288, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Radiol, Guangzhou 510080, Guangdong, Peoples R China

来源：

MOLECULAR AND CLINICAL ONCOLOGY | 2019年 / 11卷 / 03期

基金：

中国国家自然科学基金;

关键词：

breast ductal carcinoma in situ; microinvasion; sonography; mammography; BREAST-CANCER; SONOGRAPHIC FEATURES; MAMMOGRAPHY; ANGIOGENESIS; US;

D O I：

10.3892/mco.2019.1891

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with ductal carcinoma in situ with microinvasion (DCISM) have worse cancer-specific survival, disease-free survival and overall survival, and a higher mortality rate compared with patients with ductal carcinoma in situ (DCIS). Distinguishing DCISM from DCIS via preoperative imaging could help to predict the prognosis of patients. The present study compared the sonographic and mammographic features of patients with DCIS and DCISM. A total of 147 women (94 patients with DCIS and 53 patients with DCISM) were retrospectively included. The sonographic lesions were classified as either masses or non-mass abnormalities. The lesions observed on mammography were classified as calcifications only, mass, asymmetry or architectural distortion. Statistical comparisons were performed using the Mann-Whitney U test, chi(2) test, Fisher's exact test and multiple logistic regression analysis. Univariate and multivariate analyses showed that the presence of calcifications (P=0.038) and vascularity (P=0.025) on sonography were associated with DCISM. Furthermore, a lager distribution of calcifications was associated with a higher likelihood of DCISM (P=0.002). In conclusion, the presence of calcifications and vascularity on sonography or a lager distribution of calcifications on mammography may suggest DCISM.

引用

页码：313 / 319

页数：7

共 28 条

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