The practical application of three validated in vitro embryotoxicity tests -: The Report and Recommendations of an ECVAM/ZEBET Workshop (ECVAM Workshop 57)

被引：73

作者：

Spielmann, Horst ^{[1
]}

Seiler, Andrea

Bremer, Susanne

Hareng, Lars

Hartung, Thomas

Ahr, Hans

Faustman, Elaine

Haas, Ulla

Moffat, Graeme J.

Nau, Heinz

Vanparys, Philippe

Piersma, Aldert

Sintes, Juan Riego

Stuart, Jane

机构：

[1] Commiss European Communities, Joint Res Ctr, Inst Hlth & Consumer Protect, ECVAM,TP 580, I-21020 Ispra, Italy

[2] Commiss European Communities, Joint Res Ctr, Inst Hlth & Consumer Protect, ECB, I-21020 Ispra, Italy

[3] Fed Inst Risk Assessment, Ctr Documentat & Evaluat Alernat Methods Anim Exp, Berlin, Germany

[4] Bayer AG, Wuppertal, Germany

[5] Univ Washington, Dept Environm Hlth, Seattle, WA 98195 USA

[6] Inst Food Safety & Toxicol, Dept Toxicol, Soborg, Denmark

[7] Syngenta CTL, Dev Toxicol, Macclesfield, Cheshire, England

[8] Tierarztlichen Hsch Hannover, Zent Abt Lebensmitteltoxicol, D-3000 Hannover, Germany

[9] Janssen Res Fdn, Johnson & Johnson, Genet & In Vitro Toxicol, B-2340 Beerse, Belgium

[10] Natl Inst Hlth & Environm, Lab Hlth Effects, Bilthoven, Netherlands

[11] AstraZeneca Pharmaceut, Macclesfield, Cheshire, England

来源：

ATLA-ALTERNATIVES TO LABORATORY ANIMALS | 2006年 / 34卷 / 05期

关键词：

D O I：

10.1177/026119290603400504

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The major limitations of the validated in vitro embryotoxicity tests identified at the 2003 workshop were immediately taken into account by ECVAM in a proposal for an Integrated Project in the EU 6th Framework Programme, entitled ReProTect (22). Since 2004, a consortium of more than 36 laboratories involved in this project have been evaluating existing and newly developed in vitro models for reproductive processes and their integration into a testing strategy. This strategy should provide detailed information on the hazard potentials of chemicals to the mammalian reproductive cycle.

引用

页码：527 / 538

页数：12

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