Cerebral Asymmetry in Patients with Schizophrenia: A Voxel-Based Morphometry (VBM) and Diffusion Tensor Imaging (DTI) Study

被引：34
作者：
Takao, Hidemasa [1 ]
Abe, Osamu
Yamasue, Hidenori [2 ]
Aoki, Shigeki [3 ]
Kasai, Kiyoto [2 ]
Ohtomo, Kuni
机构：
[1] Univ Tokyo, Dept Radiol, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan
[2] Univ Tokyo, Dept Neuropsychiat, Grad Sch Med, Tokyo 1138655, Japan
[3] Juntendo Univ, Sch Med, Dept Radiol, Tokyo 113, Japan
来源：
JOURNAL OF MAGNETIC RESONANCE IMAGING | 2010年 / 31卷 / 01期
关键词：
asymmetry; diffusion tensor imaging; fractional anisotropy; lateralization; voxel-based morphometry; schizophrenia; PLANUM TEMPORALE ASYMMETRY; HUMAN BRAIN; VOLUME REDUCTION; MAUDSLEY FAMILY; MATTER LOSS; HANDEDNESS; MRI; GYRUS; LATERALIZATION; ABNORMALITIES;
D O I：
10.1002/jmri.22017
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Purpose: To evaluate the differences in gray- and white-matter asymmetry between schizophrenia patients and normal subjects. Materials and Methods: Forty-eight right-handed patients with chronic schizophrenia (24 males and 24 females) and 48 right-handed age-and sex-matched healthy controls (24 males and 24 females) were included in this study. The effects of diagnosis on gray-matter volume asymmetry and white-matter fractional anisotropy (FA) asymmetry were evaluated with use of voxel-based morphometry (VBM) and voxel-based analysis of FA maps derived from diffusion tensor imaging (DTI), respectively. Results: The mean gray-and white-matter volumes were significantly smaller in the schizophrenia group than in the control group. The voxel-based morphometry (VBM) showed no significant effect of diagnosis on gray-matter volume asymmetry. The voxel-based analysis of DTI also showed no significant: effect of diagnosis on white-matter FA asymmetry. Conclusion: Our results of voxel-based analyses showed no significant differences in either gray-matter Volume asymmetry or white-matter FA asymmetry between schizophrenia patients and normal subjects.
引用
收藏
页码：221 / 226
页数：6
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