Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1)

被引：18

作者：

Levi, Maya ^{[1
]}

Meijler, Michael M. ^{[2
]}

Gomez-Munoz, Antonio ^{[3
]}

Zor, Tsaffrir ^{[1
]}

机构：

[1] Tel Aviv Univ, Inst Life Sci, Dept Biochem, IL-69978 Tel Aviv, Israel

[2] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel

[3] Univ Basque Country, Dept Biochem & Mol Biol, Bilbao 48080, Spain

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2010年 / 314卷 / 02期

关键词：

Macrophages; Inflammation; C1P; PCERA-1; Phospholipid-binding receptors; Cell migration; TNF-ALPHA PRODUCTION; HIGHLY POTENT INHIBITIONS; PROTEIN-COUPLED RECEPTORS; CELL-GROWTH REGULATION; SPHINGOSINE; 1-PHOSPHATE; BLOCKS APOPTOSIS; ACID SPHINGOMYELINASE; SIGNAL-TRANSDUCTION; CHEMICAL LEADS; KINASE;

D O I：

10.1016/j.mce.2009.05.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ceramide-1-phosphate (C1P) is known as a second messenger regulating a multitude of processes including cell growth, apoptosis and inflammation. Exciting recent findings now suggest that C1P can stimulate macrophages migration in an extra-cellular manner via a G protein-coupled receptor (GPCR). Interestingly, a synthetic C1P analog, named phospho-ceramide analogue-1 (PCERA-1), was recently described as a potent in-vivo anti-inflammatory agent, and was suggested to act on macrophages in an extra-cellular manner via a GPCR. Here we summarize and compare the receptor-mediated as well as receptor-independent activities of natural C1P and its synthetic analog. We also provide experimental data in support of distinct C1P and PCERA-1 receptors. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：248 / 255

页数：8

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