Sex differences in the regulation of progesterone receptor isoforms expression in the rat brain

被引：107

作者：

Guerra-Araiza, C ^{[1
]}

Coyoy-Salgado, A ^{[1
]}

Camacho-Arroyo, I ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, Mexico

来源：

BRAIN RESEARCH BULLETIN | 2002年 / 59卷 / 02期

关键词：

progesterone receptor; progesterone; estradiol; hypothalamus; preoptic area; hippocampus;

D O I：

10.1016/S0361-9230(02)00845-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effects of estradiol (E2) and progesterone (P) on progesterone receptor (PR) isoforms gene expression in the brain of ovariectomised female and gonadectomised male rats by RT-PCR analysis. In female rats, the expression of both PR isoforms was induced by E2 and down-regulated by P in the hypothalamus, whereas in the preoptic area these changes were only observed in PR-B isoform. On the contrary, in the hippocampus and the olfactory bulb, PR-A was the isoform induced by E2. In these regions, P did not modify the expression of any PR isoform. In the cerebellum and the frontal cortex of female rats, no treatment modified PR isoforms expression. In contrast with female rats, in the male rat brain, PR isoforms expression was only modified in the cerebellum, where PR-A was induced by E2. There results demonstrate a clear sexual dimorphism in the regulation of PR isoforms expression by sex steroid hormones in the rat brain, suggesting that this sex difference contributes to the sexually dimorphic effects of P in the rat brain. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：105 / 109

页数：5

共 36 条

[1] Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior [J].

Auger, AP ;

Tetel, MJ ;

McCarthy, MM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (13) :7551-7555

[2] A SEX DIFFERENCE IN THE PROGESTIN RECEPTOR SYSTEM OF GUINEA-PIG BRAIN [J].

BLAUSTEIN, JD ;

RYER, HI ;

FEDER, HH .

NEUROENDOCRINOLOGY, 1980, 31 (06) :403-409

[3] SEX-DIFFERENCES IN ESTROGEN-RECEPTOR BINDING IN THE RAT HYPOTHALAMUS - EFFECTS OF SUBSATURATING PULSES OF ESTRADIOL [J].

BROWN, TJ ;

NAFTOLIN, F ;

MACLUSKY, NJ .

BRAIN RESEARCH, 1992, 578 (1-2) :129-134

[4] Progesterone receptor isoforms are differentially regulated by sex steroids in the rat forebrain [J].

Camacho-Arroyo, I ;

Guerra-Araiza, C ;

Cerbón, MA .

NEUROREPORT, 1998, 9 (18) :3993-3996

[5]

CAMACHOARROYO I, 1995, REV INVEST CLIN, V47, P329

[6]

CamachoArroyo I, 1996, NEUROSCI LETT, V214, P25

[7] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].

CHOMCZYNSKI, P ;

SACCHI, N .

ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159

[8] SEX-DIFFERENCES IN THE REGULATION OF OXYTOCIN RECEPTORS BY OVARIAN-STEROIDS IN THE VENTROMEDIAL HYPOTHALAMUS OF THE RAT [J].

COIRINI, H ;

JOHNSON, AE ;

SCHUMACHER, M ;

MCEWEN, BS .

NEUROENDOCRINOLOGY, 1992, 55 (03) :269-275

[9] THE A-FORMS AND B-FORMS OF THE CHICKEN PROGESTERONE-RECEPTOR ARISE BY ALTERNATE INITIATION OF TRANSLATION OF A UNIQUE MESSENGER-RNA [J].

CONNEELY, OM ;

MAXWELL, BL ;

TOFT, DO ;

SCHRADER, WT ;

OMALLEY, BW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 149 (02) :493-501

[10] Reproductive functions of the progesterone receptor isoforms: lessons from knock-out mice [J].

Conneely, OM ;

Mulac-Jericevic, B ;

Lydon, JP ;

De Mayo, FJ .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2001, 179 (1-2) :97-103

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