The multiple personality disorder phenotype(s) of circulating endothelial cells in cancer

被引：41

作者：

Bertolini, Francesco ^{[1
]}

Mancuso, Patrizia ^{[1
]}

Braidotti, Paola ^{[2
,3
]}

Shaked, Yuval ^{[4
]}

Kerbel, Robert S. ^{[5
]}

机构：

[1] European Inst Oncol, Div Hematol Oncol, Dept Med, I-20141 Milan, Italy

[2] Univ Milan, Dept Med, San Paolo Hosp, Milan, Italy

[3] IRCCS Fdn Policlin, Milan, Italy

[4] Technion Israel Inst Technol, Rappaport Fac Med, Dept Mol Pharmacol, Haifa, Israel

[5] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med Biophys, Toronto, ON M4N 3M5, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2009年 / 1796卷 / 01期

关键词：

Angiogenesis; Endothelial cells; Endothelial progenitors; MARROW-DERIVED CELLS; PROGENITOR CELLS; TUMOR ANGIOGENESIS; SURROGATE MARKER; METRONOMIC CHEMOTHERAPY; STEM-CELLS; MOBILIZATION; VIABILITY; BEVACIZUMAB; INHIBITION;

D O I：

10.1016/j.bbcan.2009.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circulating endothelial cells (CECs) and circulating endothelial progenitors (CEPs) are currently being investigated in a variety of diseases as markers of vascular turnover or damage and, also in the case of CEPs, vasculogenesis. CEPs appear to have a "catalytic" role in different steps of cancer progression and recurrence after therapy, and there are preclinical and clinical data suggesting that CEC enumeration might be useful to select and stratify patients who are candidates for anti-angiogenic treatments. In some types of cancer, CECs and CEPs might be one of the possible hidden identities of cancer stem cells. The definition of CEC and CEP phenotype and the standardization of CEC and CEP enumeration strategies are highly desirable goals in order to exploit these cells as reliable biomarkers in oncology clinical trials. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：27 / 32

页数：6

共 62 条

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