Two new phenolic compounds and antitumor activities of asparinin A from Asparagus officinalis

被引：13

作者：

Li, Xue-Mei ^{[1
,2
]}

Cai, Jin-Long ^{[1
]}

Wang, Le ^{[1
]}

Wang, Wen-Xiang ^{[1
]}

Ai, Hong-Lian ^{[1
]}

Mao, Zi-Chao ^{[2
]}

机构：

[1] South Cent Univ Nationalities, Coll Pharm, Wuhan 430074, Peoples R China

[2] Yunnan Agr Univ, Sch Agr & Biol Tech, Kunming 650201, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2017年 / 19卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Asparagus officinalis; phenolic compounds; asparinin A; antitumor; ACETYLENIC-COMPOUNDS; INHIBITORY-ACTIVITY; CONSTITUENTS; GOBICUS; PATHWAY;

D O I：

10.1080/10286020.2016.1206529

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new phenolic acid compounds, asparoffin C (1) and asparoffin D (2), together with four known compounds, asparenyol (3), gobicusin B (4), 1-methoxy-2-hydroxy-4-[5-(4-hydroxyphenoxy)-3-penten-1-ynyl] phenol (5), and asparinin A (6), have been isolated from the stems of Asparagus officinalis. The structures were established by extensive spectroscopic methods (MS and 1D and 2D NMR). Compound 6 has obvious antitumor activities both in vitro and in vivo.

引用

页码：164 / 171

页数：8

共 15 条

[1]

CAPORALI E, 1994, SEX PLANT REPROD, V7, P239, DOI 10.1007/BF00232743

[2]

Fukushi E, 2000, MAGN RESON CHEM, V38, P1005, DOI 10.1002/1097-458X(200012)38:12<1005::AID-MRC772>3.0.CO

[3]

2-Q

[4] Steroids from the roots of Asparagus officinalis and their cytotoxic activity [J].

Huang, Xue-Feng ;

Lin, Yu-Ying ;

Kong, Ling-Yi .

JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2008, 50 (06) :717-722

[5] Constituents of Asparagus officinalis evaluated for inhibitory activity against cyclooxygenase-2 [J].

Jang, DS ;

Cuendet, M ;

Fong, HHS ;

Pezzuto, JM ;

Kinghorn, AD .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (08) :2218-2222

[6]

[蒋丹 Jiang Dan], 2014, [食品工业科技, Science & Technology of Food Industry], V35, P357

[7] Two new acetylenic compounds from Asparagus officinalis [J].

Li, Xue-Mei ;

Cai, Jin-Long ;

Wang, Wen-Xiang ;

Ai, Hong-Lian ;

Mao, Zi-Chao .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2016, 18 (04) :344-348

[8] Top-down Targeted Metabolomics Reveals a Sulfur-Containing Metabolite with Inhibitory Activity against Angiotensin-Converting Enzyme in Asparagus officinalis [J].

Nakabayashi, Ryo ;

Yang, Zhigang ;

Nishizawa, Tomoko ;

Mori, Tetsuya ;

Saito, Kazuki .

JOURNAL OF NATURAL PRODUCTS, 2015, 78 (05) :1179-1183

[9]

Selvakumaran M, 2003, CANCER RES, V63, P1311

[10]

TERADA K, 1995, CHEM PHARM BULL, V43, P564, DOI 10.1248/cpb.43.564

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