Anaphase: a fortune-teller of genomic instability

被引：38
作者：
Bizard, Anna H. [1 ,2 ]
Hickson, Ian D. [1 ,2 ]
机构：
[1] Univ Copenhagen, Dept Cellular & Mol Med, Ctr Chromosome Stabil, DK-2200 Copenhagen N, Denmark
[2] Univ Copenhagen, Ctr Hlth Aging, Dept Cellular & Mol Med, DK-2200 Copenhagen N, Denmark
来源：
CURRENT OPINION IN CELL BIOLOGY | 2018年 / 52卷
基金：
新加坡国家研究基金会; 欧洲研究理事会;
关键词：
CHROMOSOME SEGREGATION ERRORS; DNA-DAMAGE; ABSCISSION CHECKPOINT; HUMAN-CELLS; BRIDGE; CHROMOTHRIPSIS; FAILURE; REPAIR; FATE; SUPPRESSION;
D O I：
10.1016/j.ceb.2018.02.012
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The anaphase of mitosis is one of the most critical stages of the cell division cycle in that it can reveal precious information on the fate of a cell lineage. Indeed, most types of nuclear DNA segregation defects visualized during anaphase are manifestations of genomic instability and augur dramatic outcomes, such as cell death or chromosomal aberrations characteristic of cancer cells. Although chromatin bridges and lagging chromatin are always pathological (generating aneuploidy or complex genomic rearrangements), the main subject of this article, the ultrafine anaphase bridges, might, in addition to potentially driving genomic instability, play critical roles for the maintenance of chromosome structure in rapidly proliferating cells.
引用
收藏
页码：112 / 119
页数：8
相关论文
共 72 条
  • [1] DNA repair pathways involved in anaphase bridge formation
    Acilan, Ceyda
    Potter, Douglas M.
    Saunders, William S.
    [J]. GENES CHROMOSOMES & CANCER, 2007, 46 (06) : 522 - 531
  • [2] Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants
    Arlt, Martin F.
    Mulle, Jennifer G.
    Schaibley, Valerie M.
    Ragland, Ryan L.
    Durkin, Sandra G.
    Warren, Stephen T.
    Glover, Thomas W.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 84 (03) : 339 - 350
  • [3] Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities
    Bakhoum, Samuel F.
    Kabeche, Lilian
    Compton, Duane A.
    Powell, Simon N.
    Bastians, Holger
    [J]. TRENDS IN CANCER, 2017, 3 (03): : 225 - 234
  • [4] The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures
    Barefield, Colleen
    Karlseder, Jan
    [J]. NUCLEIC ACIDS RESEARCH, 2012, 40 (15) : 7358 - 7367
  • [5] PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint
    Baumann, Christoph
    Koerner, Roman
    Hofmann, Kay
    Nigg, Erich A.
    [J]. CELL, 2007, 128 (01) : 101 - 114
  • [6] Bizard AH, 2014, COLD SPRING HARBOR P
  • [7] Bizard AH, 2018, METHODS MOL BIOL, V1672, P495, DOI 10.1007/978-1-4939-7306-4_33
  • [8] Centromeric Heterochromatin: The Primordial Segregation Machine
    Bloom, Kerry S.
    [J]. ANNUAL REVIEW OF GENETICS, VOL 48, 2014, 48 : 457 - 484
  • [9] TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution
    Broderick, Ronan
    Nieminuszczy, Jadwiga
    Blackford, Andrew N.
    Winczura, Alicja
    Niedzwiedz, Wojciech
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [10] Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites
    Burrow, Allison A.
    Williams, Laura E.
    Pierce, Levi C. T.
    Wang, Yuh-Hwa
    [J]. BMC GENOMICS, 2009, 10
12345678