Anaphase: a fortune-teller of genomic instability

被引：41

作者：

Bizard, Anna H. ^{[1
,2
]}

Hickson, Ian D. ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Dept Cellular & Mol Med, Ctr Chromosome Stabil, DK-2200 Copenhagen N, Denmark

[2] Univ Copenhagen, Ctr Hlth Aging, Dept Cellular & Mol Med, DK-2200 Copenhagen N, Denmark

来源：

CURRENT OPINION IN CELL BIOLOGY | 2018年 / 52卷

基金：

新加坡国家研究基金会; 欧洲研究理事会;

关键词：

CHROMOSOME SEGREGATION ERRORS; DNA-DAMAGE; ABSCISSION CHECKPOINT; HUMAN-CELLS; BRIDGE; CHROMOTHRIPSIS; FAILURE; REPAIR; FATE; SUPPRESSION;

D O I：

10.1016/j.ceb.2018.02.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The anaphase of mitosis is one of the most critical stages of the cell division cycle in that it can reveal precious information on the fate of a cell lineage. Indeed, most types of nuclear DNA segregation defects visualized during anaphase are manifestations of genomic instability and augur dramatic outcomes, such as cell death or chromosomal aberrations characteristic of cancer cells. Although chromatin bridges and lagging chromatin are always pathological (generating aneuploidy or complex genomic rearrangements), the main subject of this article, the ultrafine anaphase bridges, might, in addition to potentially driving genomic instability, play critical roles for the maintenance of chromosome structure in rapidly proliferating cells.

引用

页码：112 / 119

页数：8

共 72 条

[1] DNA repair pathways involved in anaphase bridge formation [J].